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- W2023559199 abstract "Vitamin D plays an important and increasingly understood role in muscle health and performance. Vitamin D exhibits a nuclear receptor for transcription interaction and a transmembrane receptor, giving it genomic and non-genomic interactions. Vitamin D receptors have been described that affect muscle function. Vitamin D has also been correlated with muscle performance. Beyond its role in normal muscle function, vitamin D deficiency can interact with statins to produce myalgia-myositis, which can be reversed by normalizing serum vitamin D [7,13]. Exertional rhabdomyolysis may occur in diverse settings including marathons, ice skating, bicycling and swimming. Our hypothesis is that subjects with pre-existing low serum 25OHD are selected out for exertional rhabdomyolysis during strenuous activities.We review exercise induced severe rhabdomyolysis in association with heat stroke with subsequent disseminated intravascular coagulation in a thin, athletic, dark skinned, conditioned young man, occurring in the setting of a 5K race, subsequently found to have severe 25 OH vitamin D deficiency (6 ng/ml, laboratory lower normal limit>30 ng/ml).We suggest that when very low vitamin D is documented, it be normalized before major prolonged exertion. We hypothesize that normalization of vitamin D before heavy exertion could perhaps prevent the severe muscle damage events and sequelae as was the case for this patient." @default.
- W2023559199 created "2016-06-24" @default.
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- W2023559199 date "2013-10-01" @default.
- W2023559199 modified "2023-09-26" @default.
- W2023559199 title "Does low serum 25 OH vitamin D interact with very strenuous physical activity, facilitating development of rhabdomyolysis?" @default.
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- W2023559199 doi "https://doi.org/10.1016/j.mehy.2013.06.029" @default.
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