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- W2023559246 abstract "The effects of scopolamine hydrobromide (2.0 mg/kg) and d -amphetamine sulfate (3.0 mg/kg) were evaluated in a water-approach task following stimulus preexposure and in the habituation of locomotor activity. Stimulus preexposure reduced the response rate of approaching a water source upon reexposure to the stimulus complex. Strain differences between DBA/2J and C57BL/6J mice were observed in the effects of the preexposure treatment, although the approach rate was directly related to the duration of preexposure in both strains. Although scopolamine and d -amphetamine differentially affected locomotor activity in the two strains, both drugs eliminated the effects of preexposure and attenuated the course of habituation of locomotor activity equally in DBA/2J and C57BL/6J mice. In addition, d -amphetamine produced carryover effects in terms of increased locomotor activity. Results were interpreted in terms of the immediate and carryover effects elicited by the drugs, i.e., response disinhibition/dishabituation in the case of scopolamine and genuine response excitation with d -amphetamine. Alternative explanations such as proactive drug effects, effects on memory consolidation, drug dissociation, or drug × deprivation interaction did not account for the observed findings." @default.
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- W2023559246 title "Differentiation of response biases elicited by scopolamine and d-amphetamine: effects on habituation" @default.
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- W2023559246 doi "https://doi.org/10.1016/s0091-6773(76)92407-x" @default.
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