Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023559564> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2023559564 endingPage "287" @default.
- W2023559564 startingPage "281" @default.
- W2023559564 abstract "Transferrin receptor (TfR) is a dimeric transmembrane protein that provides iron transport from plasma to cells by binding and internalization of iron-loaded transferrin (Tf). Soluble transferrin receptor (sTfR) is an extracellular part of the TfR molecule that is truncated from the cell surface and released into the blood stream. Using monoclonal antibodies (HyTest Ltd., Turku, Finland), immunofluorescent methods for sTfR and sTfR–Tf complex determination were developed. Soluble TfR was isolated from human plasma, and complex formation between sTfR and Tf was studied by stepwise complex construction and by FPLC gel filtration. It was found that sTfR could bind two Tf molecules step by step when the sTfR–Tf complex is constructed in the plate wells. FPLC gel filtration of sTfR–Tf mixtures and analysis of sTfR and sTfR–Tf immunological activities in collected fractions showed that sTfR can form different complexes with TF depending upon the ratios between them: a 291-kDa compound is assumed to be a 2:1 sTfR/Tf complex, and a 345-kDa compound is assumed to be a 2:2 sTfR/Tf complex. Isolated sTfR eluted as a 237-kDa protein. FPLC gel filtration of serum revealed that all sTfR in serum is bound to Tf in a 2:2 complex, and no isolated sTfR can be found in serum. This raises the question as to the nature of the bonds that hold two molecules of sTfR together to form a dimer. Am. J. Hematol. 79:281–287, 2005. © 2005 Wiley-Liss, Inc." @default.
- W2023559564 created "2016-06-24" @default.
- W2023559564 creator A5005809452 @default.
- W2023559564 creator A5007668914 @default.
- W2023559564 creator A5025952507 @default.
- W2023559564 creator A5035500096 @default.
- W2023559564 creator A5040968339 @default.
- W2023559564 creator A5056323776 @default.
- W2023559564 date "2005-01-01" @default.
- W2023559564 modified "2023-09-27" @default.
- W2023559564 title "Immunological study of complex formation between soluble transferrin receptor and transferrin" @default.
- W2023559564 cites W1557894700 @default.
- W2023559564 cites W1575133603 @default.
- W2023559564 cites W1579613226 @default.
- W2023559564 cites W1588054335 @default.
- W2023559564 cites W1872922503 @default.
- W2023559564 cites W1892955621 @default.
- W2023559564 cites W1962690668 @default.
- W2023559564 cites W1985186978 @default.
- W2023559564 cites W2013759064 @default.
- W2023559564 cites W2018474214 @default.
- W2023559564 cites W2019757220 @default.
- W2023559564 cites W2021859285 @default.
- W2023559564 cites W2029372598 @default.
- W2023559564 cites W2093902483 @default.
- W2023559564 cites W2098058233 @default.
- W2023559564 cites W2100837269 @default.
- W2023559564 cites W2129309714 @default.
- W2023559564 cites W2152058159 @default.
- W2023559564 cites W2157410701 @default.
- W2023559564 cites W4250269528 @default.
- W2023559564 doi "https://doi.org/10.1002/ajh.20429" @default.
- W2023559564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16044455" @default.
- W2023559564 hasPublicationYear "2005" @default.
- W2023559564 type Work @default.
- W2023559564 sameAs 2023559564 @default.
- W2023559564 citedByCount "6" @default.
- W2023559564 countsByYear W20235595642013 @default.
- W2023559564 countsByYear W20235595642017 @default.
- W2023559564 crossrefType "journal-article" @default.
- W2023559564 hasAuthorship W2023559564A5005809452 @default.
- W2023559564 hasAuthorship W2023559564A5007668914 @default.
- W2023559564 hasAuthorship W2023559564A5025952507 @default.
- W2023559564 hasAuthorship W2023559564A5035500096 @default.
- W2023559564 hasAuthorship W2023559564A5040968339 @default.
- W2023559564 hasAuthorship W2023559564A5056323776 @default.
- W2023559564 hasBestOaLocation W20235595641 @default.
- W2023559564 hasConcept C153911025 @default.
- W2023559564 hasConcept C159654299 @default.
- W2023559564 hasConcept C181199279 @default.
- W2023559564 hasConcept C185592680 @default.
- W2023559564 hasConcept C195310446 @default.
- W2023559564 hasConcept C203014093 @default.
- W2023559564 hasConcept C22814914 @default.
- W2023559564 hasConcept C32264632 @default.
- W2023559564 hasConcept C542903549 @default.
- W2023559564 hasConcept C55493867 @default.
- W2023559564 hasConcept C86803240 @default.
- W2023559564 hasConceptScore W2023559564C153911025 @default.
- W2023559564 hasConceptScore W2023559564C159654299 @default.
- W2023559564 hasConceptScore W2023559564C181199279 @default.
- W2023559564 hasConceptScore W2023559564C185592680 @default.
- W2023559564 hasConceptScore W2023559564C195310446 @default.
- W2023559564 hasConceptScore W2023559564C203014093 @default.
- W2023559564 hasConceptScore W2023559564C22814914 @default.
- W2023559564 hasConceptScore W2023559564C32264632 @default.
- W2023559564 hasConceptScore W2023559564C542903549 @default.
- W2023559564 hasConceptScore W2023559564C55493867 @default.
- W2023559564 hasConceptScore W2023559564C86803240 @default.
- W2023559564 hasIssue "4" @default.
- W2023559564 hasLocation W20235595641 @default.
- W2023559564 hasLocation W20235595642 @default.
- W2023559564 hasOpenAccess W2023559564 @default.
- W2023559564 hasPrimaryLocation W20235595641 @default.
- W2023559564 hasRelatedWork W1980218229 @default.
- W2023559564 hasRelatedWork W2079888525 @default.
- W2023559564 hasRelatedWork W2093345048 @default.
- W2023559564 hasRelatedWork W2130255055 @default.
- W2023559564 hasRelatedWork W2395184307 @default.
- W2023559564 hasRelatedWork W2421374273 @default.
- W2023559564 hasRelatedWork W2427549412 @default.
- W2023559564 hasRelatedWork W2439555115 @default.
- W2023559564 hasRelatedWork W2463373043 @default.
- W2023559564 hasRelatedWork W2603041700 @default.
- W2023559564 hasVolume "79" @default.
- W2023559564 isParatext "false" @default.
- W2023559564 isRetracted "false" @default.
- W2023559564 magId "2023559564" @default.
- W2023559564 workType "article" @default.