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• W2023561229 abstract "Resistance to experimental allergic encephalomyelitis (EAE) induction by homogenized myelin (MSCH) in complete Freund's adjuvant (CFA) and pertussigen (P) in SJL mice was seen 1 week after intravenous injection of PLP 139–151 coupled to spleen cells (PLP-ECDI-SP). Although this resistance could be transferred by spleen cells enriched for CD8+ T cells and thus had a component of immunoregulatory T cells, it was primarily due to anergy, as it was reversible by four daily injections of interleukin (II)-2 starting 3 days after the PLP-ECDI-SP. Earlier treatment with IL-2 did not reverse the tolerance. In view of the known higher sensitivity to anergy induction of Th1 than of Th2 cells, a change in the cytokine balance in the response to MSCH + CFA after anergy induction might be responsible for the resistance to EAE induction. The effect of treatment with cytokines alone on induction of EAE was therefore also determined. Short-term (1–2 weeks) daily pretreatment with IL-2 (4000 U) or TGF-β2 (1 μ g) somewhat decreased the susceptibility to subsequent EAE induction, but IL-4 (5 ng), IL-10 (5 μ g) or IL-12 (50–200 ng) had no effect under those conditions, even if low doses of PLP were injected simultaneously. Daily injections of IL-4 over an 8-week period prior to immunization, however, significantly lowered the incidence of EAE. Simultaneous injections of IFN-γ (2000 U/day) completely abolished this effect of IL-4. The effect of these cytokines administered immediately after the immunization with MSCH + CFA + P was also examined. As shown earlier, TGF-β2 (100–1000 ng/day) caused a marked protection when it was given intraperitoneally on days 5–9 after injection of MSCH + CFA. IL-4 (5 ng/day), in contrast, was very protective when administered on days 0–4 and less so when given on days 5–9 or even on days 0–12. IL-10 (1 μg/day) was not protective under these conditions and IL-12 (50 ng/day) significantly increased the severity and mortality of EAE when given on days 0–4 after MSCH + CFA." @default.
• W2023561229 created "2016-06-24" @default.
• W2023561229 creator A5010207886 @default.
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• W2023561229 date "1995-05-01" @default.
• W2023561229 modified "2023-09-30" @default.
• W2023561229 title "Tolerogenic forms of auto-antigens and cytokines in the induction of resistance to experimental allergic encephalomyelitis" @default.
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