Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023562457> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2023562457 endingPage "62" @default.
- W2023562457 startingPage "59" @default.
- W2023562457 abstract "Death represents the main hallmark of amyotrophic lateral sclerosis (ALS). Despite its importance in clinical care and phase III trials, many uncertainties remain on the cause of death due to the lack of post-mortem verifications. To provide a more robust approach to these causes, we performed a retrospective pathological study on a large cohort of patients. 100 ALS patients referred for a deterioration of their clinical condition and who died in the ALS clinic of Salpétrière had a complete macroscopic and microscopic post-mortem analysis. The clinical causes of death reported on medical records were compared to the results of autopsy. The concordance between clinical and pathological conclusions was insufficient (20%) to consider clinical assessment as a reliable marker of causes of death. At autopsy, broncho-pneumonia and pneumonia were the main causes of death. Heart failure, representing 10% of deaths, was two times more frequent in bulbar than in spinal ALS. Pulmonary embolism representing 6% of death was exclusively found in spinal onset patients and is related to lower limbs disability. An effort has to be made for a better understanding of the causes of deterioration of ALS patients. A more proactive attitude to treat respiratory infections could have a significant impact on survival." @default.
- W2023562457 created "2016-06-24" @default.
- W2023562457 creator A5004501662 @default.
- W2023562457 creator A5006151659 @default.
- W2023562457 creator A5016990492 @default.
- W2023562457 creator A5024570101 @default.
- W2023562457 creator A5039614344 @default.
- W2023562457 creator A5055109789 @default.
- W2023562457 creator A5057953137 @default.
- W2023562457 creator A5067355239 @default.
- W2023562457 date "2008-01-01" @default.
- W2023562457 modified "2023-10-14" @default.
- W2023562457 title "Causes of death in a post‐mortem series of ALS patients" @default.
- W2023562457 cites W1558879832 @default.
- W2023562457 cites W1998513792 @default.
- W2023562457 cites W1999387079 @default.
- W2023562457 cites W2007478642 @default.
- W2023562457 cites W2016309560 @default.
- W2023562457 cites W2050860956 @default.
- W2023562457 cites W2061504347 @default.
- W2023562457 cites W2063396825 @default.
- W2023562457 cites W2064471644 @default.
- W2023562457 cites W2078537626 @default.
- W2023562457 cites W4237126259 @default.
- W2023562457 cites W92741982 @default.
- W2023562457 doi "https://doi.org/10.1080/17482960701656940" @default.
- W2023562457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17924236" @default.
- W2023562457 hasPublicationYear "2008" @default.
- W2023562457 type Work @default.
- W2023562457 sameAs 2023562457 @default.
- W2023562457 citedByCount "136" @default.
- W2023562457 countsByYear W20235624572012 @default.
- W2023562457 countsByYear W20235624572013 @default.
- W2023562457 countsByYear W20235624572014 @default.
- W2023562457 countsByYear W20235624572015 @default.
- W2023562457 countsByYear W20235624572016 @default.
- W2023562457 countsByYear W20235624572017 @default.
- W2023562457 countsByYear W20235624572018 @default.
- W2023562457 countsByYear W20235624572019 @default.
- W2023562457 countsByYear W20235624572020 @default.
- W2023562457 countsByYear W20235624572021 @default.
- W2023562457 countsByYear W20235624572022 @default.
- W2023562457 countsByYear W20235624572023 @default.
- W2023562457 crossrefType "journal-article" @default.
- W2023562457 hasAuthorship W2023562457A5004501662 @default.
- W2023562457 hasAuthorship W2023562457A5006151659 @default.
- W2023562457 hasAuthorship W2023562457A5016990492 @default.
- W2023562457 hasAuthorship W2023562457A5024570101 @default.
- W2023562457 hasAuthorship W2023562457A5039614344 @default.
- W2023562457 hasAuthorship W2023562457A5055109789 @default.
- W2023562457 hasAuthorship W2023562457A5057953137 @default.
- W2023562457 hasAuthorship W2023562457A5067355239 @default.
- W2023562457 hasConcept C126322002 @default.
- W2023562457 hasConcept C160798450 @default.
- W2023562457 hasConcept C167135981 @default.
- W2023562457 hasConcept C177713679 @default.
- W2023562457 hasConcept C207886595 @default.
- W2023562457 hasConcept C2776888751 @default.
- W2023562457 hasConcept C2777914695 @default.
- W2023562457 hasConcept C2779134260 @default.
- W2023562457 hasConcept C2779504383 @default.
- W2023562457 hasConcept C2780596555 @default.
- W2023562457 hasConcept C29374701 @default.
- W2023562457 hasConcept C535046627 @default.
- W2023562457 hasConcept C71924100 @default.
- W2023562457 hasConceptScore W2023562457C126322002 @default.
- W2023562457 hasConceptScore W2023562457C160798450 @default.
- W2023562457 hasConceptScore W2023562457C167135981 @default.
- W2023562457 hasConceptScore W2023562457C177713679 @default.
- W2023562457 hasConceptScore W2023562457C207886595 @default.
- W2023562457 hasConceptScore W2023562457C2776888751 @default.
- W2023562457 hasConceptScore W2023562457C2777914695 @default.
- W2023562457 hasConceptScore W2023562457C2779134260 @default.
- W2023562457 hasConceptScore W2023562457C2779504383 @default.
- W2023562457 hasConceptScore W2023562457C2780596555 @default.
- W2023562457 hasConceptScore W2023562457C29374701 @default.
- W2023562457 hasConceptScore W2023562457C535046627 @default.
- W2023562457 hasConceptScore W2023562457C71924100 @default.
- W2023562457 hasIssue "1" @default.
- W2023562457 hasLocation W20235624571 @default.
- W2023562457 hasLocation W20235624572 @default.
- W2023562457 hasOpenAccess W2023562457 @default.
- W2023562457 hasPrimaryLocation W20235624571 @default.
- W2023562457 hasRelatedWork W1979912808 @default.
- W2023562457 hasRelatedWork W1981440041 @default.
- W2023562457 hasRelatedWork W1999018812 @default.
- W2023562457 hasRelatedWork W2023562457 @default.
- W2023562457 hasRelatedWork W2313265505 @default.
- W2023562457 hasRelatedWork W2358444632 @default.
- W2023562457 hasRelatedWork W2387463386 @default.
- W2023562457 hasRelatedWork W2409371358 @default.
- W2023562457 hasRelatedWork W2414059568 @default.
- W2023562457 hasRelatedWork W3003753046 @default.
- W2023562457 hasVolume "9" @default.
- W2023562457 isParatext "false" @default.
- W2023562457 isRetracted "false" @default.
- W2023562457 magId "2023562457" @default.
- W2023562457 workType "article" @default.