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- W2023562976 abstract "High concentrations of the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium ion (MPP+) are toxic to the catecholaminergic cell line PC12, derived from rat phenochromocytoma. Prolonged exposure of wild-type PC12 cells to 500 microM MPP+ yields toxin-resistant colonies at a frequency of 2 X 10(-4). These spontaneously arising MPP(+)-resistant cells are morphologically quite distinct from wild-type PC12 cells, and are lacking in most of their characteristic catecholaminergic properties. In contrast, among PC12 cells infected with the murine retrovirus ZIPNEOSV(X), 20% are resistant to the toxin MPP+, a resistance frequency approximately 1,000 times higher than for uninfected cells. The morphology and catecholaminergic phenotype of the virus-infected MPP+ resistant cells are quite similar to those of wild-type PC12 cells. The results presented in this study suggest a unique mechanism of MPP+ resistance in the infected PC12 cells which may be conferred by the presence and/or expression of the retrovirus ZIPNEOSV(X)." @default.
- W2023562976 created "2016-06-24" @default.
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- W2023562976 date "1990-09-01" @default.
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- W2023562976 title "Infection with Murine Retrovirus Confers Resistance to the Neurotoxin 1-Methyl-4-Phenylpyridinium Ion in PC12 Cells" @default.
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- W2023562976 doi "https://doi.org/10.1111/j.1471-4159.1990.tb04570.x" @default.
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