FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023563118> ?p ?o ?g. }

• W2023563118 endingPage "1606" @default.
• W2023563118 startingPage "1597" @default.
• W2023563118 abstract "Ischemia-reperfusion injury (IRI) is a major limiting event for successful liver transplantation, and CD4+ T cells and invariant natural killer T (iNKT) cells have been implicated in promoting IRI. We hypothesized that hepatic overexpression of CD39, an ectonucleotidase with antiinflammatory functions, will protect liver grafts after prolonged cold ischemia. CD39-transgenic (CD39tg) and wildtype (WT) mouse livers were transplanted into WT recipients after 18 hours cold storage and pathological analysis was performed 6 hours after transplantation. Serum levels of alanine aminotransferase and interleukin (IL)-6 were significantly reduced in recipients of CD39tg livers compared to recipients of WT livers. Furthermore, less severe histopathological injury was demonstrated in the CD39tg grafts. Immune analysis revealed that CD4+ T cells and iNKT cells were significantly decreased in number in the livers of untreated CD39tg mice. This was associated with a peripheral CD4+ T cell lymphopenia due to defective thymocyte maturation. To assess the relative importance of liver-resident CD4+ T cells and iNKT cells in mediating liver injury following extended cold preservation and transplantation, WT mice depleted of CD4+ T cells or mice genetically deficient in iNKT cells were used as donors. The absence of CD4+ T cells, but not iNKT cells, protected liver grafts from early IRI. Conclusion: Hepatic CD4+ T cells, but not iNKT cells, play a critical role in early IRI following extended cold preservation in a liver transplant model. (HEPATOLOGY 2013)" @default.
• W2023563118 created "2016-06-24" @default.
• W2023563118 creator A5021556566 @default.
• W2023563118 creator A5024213819 @default.
• W2023563118 creator A5039238202 @default.
• W2023563118 creator A5041621533 @default.
• W2023563118 creator A5047414830 @default.
• W2023563118 creator A5055801882 @default.
• W2023563118 creator A5056439193 @default.
• W2023563118 creator A5065307536 @default.
• W2023563118 creator A5067910050 @default.
• W2023563118 creator A5087469773 @default.
• W2023563118 date "2013-03-14" @default.
• W2023563118 modified "2023-10-07" @default.
• W2023563118 title "Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4⁺T cells" @default.
• W2023563118 cites W1512779544 @default.
• W2023563118 cites W1517393168 @default.
• W2023563118 cites W15188377 @default.
• W2023563118 cites W1522010565 @default.
• W2023563118 cites W1548333203 @default.
• W2023563118 cites W162447880 @default.
• W2023563118 cites W1792542720 @default.
• W2023563118 cites W1842545013 @default.
• W2023563118 cites W1978910929 @default.
• W2023563118 cites W1979024995 @default.
• W2023563118 cites W1988951550 @default.
• W2023563118 cites W1990312588 @default.
• W2023563118 cites W1990387060 @default.
• W2023563118 cites W1992328646 @default.
• W2023563118 cites W1993324234 @default.
• W2023563118 cites W1994008257 @default.
• W2023563118 cites W2002566701 @default.
• W2023563118 cites W2009924963 @default.
• W2023563118 cites W2019731712 @default.
• W2023563118 cites W2036750318 @default.
• W2023563118 cites W2053763669 @default.
• W2023563118 cites W2054295432 @default.
• W2023563118 cites W2060927696 @default.
• W2023563118 cites W2067223216 @default.
• W2023563118 cites W2074156869 @default.
• W2023563118 cites W2097354544 @default.
• W2023563118 cites W2098663684 @default.
• W2023563118 cites W2099465341 @default.
• W2023563118 cites W2106190040 @default.
• W2023563118 cites W2108589013 @default.
• W2023563118 cites W2123111978 @default.
• W2023563118 cites W2125075553 @default.
• W2023563118 cites W2143498810 @default.
• W2023563118 cites W2150083988 @default.
• W2023563118 cites W2165167811 @default.
• W2023563118 cites W2166702711 @default.
• W2023563118 cites W2169825634 @default.
• W2023563118 cites W2171946189 @default.
• W2023563118 cites W4229980946 @default.
• W2023563118 doi "https://doi.org/10.1002/hep.25985" @default.
• W2023563118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22829222" @default.
• W2023563118 hasPublicationYear "2013" @default.
• W2023563118 type Work @default.
• W2023563118 sameAs 2023563118 @default.
• W2023563118 citedByCount "40" @default.
• W2023563118 countsByYear W20235631182012 @default.
• W2023563118 countsByYear W20235631182013 @default.
• W2023563118 countsByYear W20235631182014 @default.
• W2023563118 countsByYear W20235631182015 @default.
• W2023563118 countsByYear W20235631182016 @default.
• W2023563118 countsByYear W20235631182017 @default.
• W2023563118 countsByYear W20235631182018 @default.
• W2023563118 countsByYear W20235631182019 @default.
• W2023563118 countsByYear W20235631182020 @default.
• W2023563118 countsByYear W20235631182021 @default.
• W2023563118 countsByYear W20235631182022 @default.
• W2023563118 countsByYear W20235631182023 @default.
• W2023563118 crossrefType "journal-article" @default.
• W2023563118 hasAuthorship W2023563118A5021556566 @default.
• W2023563118 hasAuthorship W2023563118A5024213819 @default.
• W2023563118 hasAuthorship W2023563118A5039238202 @default.
• W2023563118 hasAuthorship W2023563118A5041621533 @default.
• W2023563118 hasAuthorship W2023563118A5047414830 @default.
• W2023563118 hasAuthorship W2023563118A5055801882 @default.
• W2023563118 hasAuthorship W2023563118A5056439193 @default.
• W2023563118 hasAuthorship W2023563118A5065307536 @default.
• W2023563118 hasAuthorship W2023563118A5067910050 @default.
• W2023563118 hasAuthorship W2023563118A5087469773 @default.
• W2023563118 hasBestOaLocation W20235631182 @default.
• W2023563118 hasConcept C102230213 @default.
• W2023563118 hasConcept C104317684 @default.
• W2023563118 hasConcept C113278225 @default.
• W2023563118 hasConcept C126322002 @default.
• W2023563118 hasConcept C134018914 @default.
• W2023563118 hasConcept C141035611 @default.
• W2023563118 hasConcept C142724271 @default.
• W2023563118 hasConcept C203014093 @default.
• W2023563118 hasConcept C2776090121 @default.
• W2023563118 hasConcept C2776637226 @default.
• W2023563118 hasConcept C2778954852 @default.
• W2023563118 hasConcept C2779609443 @default.
• W2023563118 hasConcept C2780114680 @default.
• W2023563118 hasConcept C2911091166 @default.

• next