FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023563651> ?p ?o ?g. }

• W2023563651 endingPage "34" @default.
• W2023563651 startingPage "29" @default.
• W2023563651 abstract "Recent data from several groups suggest that the primary mechanism of amyloid β-protein (Aβ) neurotoxicity may be mediated by free radicals. To evaluate this hypothesis, our aim is to make the mechanism of Aβ neurotoxicity clear, especially in the formation of free radicals. In this study, rat pheochromocytoma (PC12) cells were exposed to Aβ25–35 and confirmed free radical generations using two kinds of spin trap agents, 5,5-dimethyl-1-pyrroline-N-oxide; DMPO and α-(4-pyridyl-1-oxide)-N-tert-butylnitrone; POBN. DMPO spin adduct revealed that hydroxyl radical (OH), while POBN spin adduct identified a lipid radical (L) as electron paramagnetic resonance (EPR) evidence of lipid peroxidation in the process of cell damage by Aβ25–35 exposure. An Aβ cytotoxicity assay also was performed by using WST-8 reduction system and histochemical analysis. These analyses showed cell damage induced by Aβ. This study provides EPR evidence that Aβ neurotoxicity is derived from hydrogen abstraction from polyunsaturated lipid acid by hydroxyl radical as a cause of lipid peroxidation." @default.
• W2023563651 created "2016-06-24" @default.
• W2023563651 creator A5017258609 @default.
• W2023563651 creator A5046832503 @default.
• W2023563651 creator A5075784726 @default.
• W2023563651 creator A5085011782 @default.
• W2023563651 date "2004-10-01" @default.
• W2023563651 modified "2023-09-24" @default.
• W2023563651 title "EPR evidence of hydroxyl radical generation as an initiator of lipid peroxidation in amyloid β-protein-stimulated PC12 cells" @default.
• W2023563651 cites W1969810313 @default.
• W2023563651 cites W1982063629 @default.
• W2023563651 cites W1984202672 @default.
• W2023563651 cites W1986318523 @default.
• W2023563651 cites W1991691896 @default.
• W2023563651 cites W1994297509 @default.
• W2023563651 cites W1996579240 @default.
• W2023563651 cites W1997858074 @default.
• W2023563651 cites W2014094971 @default.
• W2023563651 cites W2029552699 @default.
• W2023563651 cites W2033017137 @default.
• W2023563651 cites W2044942478 @default.
• W2023563651 cites W2048889423 @default.
• W2023563651 cites W2049167261 @default.
• W2023563651 cites W2051267637 @default.
• W2023563651 cites W2059214757 @default.
• W2023563651 cites W2070117026 @default.
• W2023563651 cites W2077247875 @default.
• W2023563651 cites W2078832316 @default.
• W2023563651 cites W2079887405 @default.
• W2023563651 cites W2081569845 @default.
• W2023563651 cites W2083500052 @default.
• W2023563651 cites W2089486469 @default.
• W2023563651 cites W2090150925 @default.
• W2023563651 cites W2108574477 @default.
• W2023563651 cites W2120648922 @default.
• W2023563651 cites W2122056834 @default.
• W2023563651 cites W2131633241 @default.
• W2023563651 cites W2148999943 @default.
• W2023563651 cites W2158748165 @default.
• W2023563651 cites W2314008219 @default.
• W2023563651 cites W4242452661 @default.
• W2023563651 doi "https://doi.org/10.1016/j.brainres.2004.07.067" @default.
• W2023563651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15464741" @default.
• W2023563651 hasPublicationYear "2004" @default.
• W2023563651 type Work @default.
• W2023563651 sameAs 2023563651 @default.
• W2023563651 citedByCount "12" @default.
• W2023563651 countsByYear W20235636512012 @default.
• W2023563651 countsByYear W20235636512015 @default.
• W2023563651 countsByYear W20235636512020 @default.
• W2023563651 crossrefType "journal-article" @default.
• W2023563651 hasAuthorship W2023563651A5017258609 @default.
• W2023563651 hasAuthorship W2023563651A5046832503 @default.
• W2023563651 hasAuthorship W2023563651A5075784726 @default.
• W2023563651 hasAuthorship W2023563651A5085011782 @default.
• W2023563651 hasConcept C121332964 @default.
• W2023563651 hasConcept C12554922 @default.
• W2023563651 hasConcept C139066938 @default.
• W2023563651 hasConcept C178790620 @default.
• W2023563651 hasConcept C185592680 @default.
• W2023563651 hasConcept C187961010 @default.
• W2023563651 hasConcept C2776778087 @default.
• W2023563651 hasConcept C2778004101 @default.
• W2023563651 hasConcept C2778815226 @default.
• W2023563651 hasConcept C2779491297 @default.
• W2023563651 hasConcept C2780829032 @default.
• W2023563651 hasConcept C29730261 @default.
• W2023563651 hasConcept C46141821 @default.
• W2023563651 hasConcept C55493867 @default.
• W2023563651 hasConcept C60642223 @default.
• W2023563651 hasConcept C86803240 @default.
• W2023563651 hasConceptScore W2023563651C121332964 @default.
• W2023563651 hasConceptScore W2023563651C12554922 @default.
• W2023563651 hasConceptScore W2023563651C139066938 @default.
• W2023563651 hasConceptScore W2023563651C178790620 @default.
• W2023563651 hasConceptScore W2023563651C185592680 @default.
• W2023563651 hasConceptScore W2023563651C187961010 @default.
• W2023563651 hasConceptScore W2023563651C2776778087 @default.
• W2023563651 hasConceptScore W2023563651C2778004101 @default.
• W2023563651 hasConceptScore W2023563651C2778815226 @default.
• W2023563651 hasConceptScore W2023563651C2779491297 @default.
• W2023563651 hasConceptScore W2023563651C2780829032 @default.
• W2023563651 hasConceptScore W2023563651C29730261 @default.
• W2023563651 hasConceptScore W2023563651C46141821 @default.
• W2023563651 hasConceptScore W2023563651C55493867 @default.
• W2023563651 hasConceptScore W2023563651C60642223 @default.
• W2023563651 hasConceptScore W2023563651C86803240 @default.
• W2023563651 hasFunder F4320320912 @default.
• W2023563651 hasIssue "1-2" @default.
• W2023563651 hasLocation W20235636511 @default.
• W2023563651 hasLocation W20235636512 @default.
• W2023563651 hasOpenAccess W2023563651 @default.
• W2023563651 hasPrimaryLocation W20235636511 @default.
• W2023563651 hasRelatedWork W134642537 @default.
• W2023563651 hasRelatedWork W1794504923 @default.
• W2023563651 hasRelatedWork W2004088421 @default.
• W2023563651 hasRelatedWork W2023563651 @default.
• W2023563651 hasRelatedWork W2053381403 @default.

• next