FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023563658> ?p ?o ?g. }

• W2023563658 endingPage "210" @default.
• W2023563658 startingPage "203" @default.
• W2023563658 abstract "CD-349 (2-nitratopropyl 3-nitratopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate) inhibited the activity of cyclic AMP phosphodiesterase (PDE) from the porcine coronary artery more effectively than that from the myocardium. Other dihydropyridines, nicardipine and nifedipine, were not tissue selective in inhibiting the cyclic AMP PDE from both sources. CD-349 inhibited cyclic AMP PDE noncompetitively with apparent inhibition constant (K1) values of 6.6 and 4.6 microM for high and low affinity constant (Km) enzymes, respectively. Basal activity of coronary arterial cyclic AMP PDE was decreased to approximately 65% of the control value by 0.2 mM ethylene glycol bis (beta-amino-ethyl ether) N,N,N',N'-tetraacetic acid (EGTA). In the coronary artery, the inhibition of cyclic AMP PDE by CD-349 was weakened in the presence of EGTA, while the inhibition of nicardipine and nifedipine were not affected. EGTA had no influence on the CD-349 induced inhibition of myocardial cyclic AMP PDE. Calmodulin antagonists such as trifluoperazine (TFP) gave substantially the same results as those with CD-349. These results indicate the relative selectivity of the coronary arterial cyclic AMP PDE inhibition by CD-349 and suggest that this selective inhibition is due to blockade of calcium/calmodulin-activated cyclic AMP PDE." @default.
• W2023563658 created "2016-06-24" @default.
• W2023563658 creator A5022043062 @default.
• W2023563658 creator A5032673230 @default.
• W2023563658 creator A5037866444 @default.
• W2023563658 date "1987-01-01" @default.
• W2023563658 modified "2023-10-14" @default.
• W2023563658 title "Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by CD-349, a novel 1,4-dihydropyridine derivative: Effect of EGTA on the inhibitory activity." @default.
• W2023563658 cites W1499756232 @default.
• W2023563658 cites W1512899424 @default.
• W2023563658 cites W1572735837 @default.
• W2023563658 cites W1606518258 @default.
• W2023563658 cites W1775749144 @default.
• W2023563658 cites W1991141881 @default.
• W2023563658 cites W1998687037 @default.
• W2023563658 cites W2025833044 @default.
• W2023563658 cites W2031462923 @default.
• W2023563658 cites W2033893181 @default.
• W2023563658 cites W2043563082 @default.
• W2023563658 cites W2050049694 @default.
• W2023563658 cites W2052327171 @default.
• W2023563658 cites W2067192530 @default.
• W2023563658 cites W2077936658 @default.
• W2023563658 cites W2079354934 @default.
• W2023563658 cites W2081330336 @default.
• W2023563658 cites W2086635215 @default.
• W2023563658 cites W2089180548 @default.
• W2023563658 cites W2107108585 @default.
• W2023563658 cites W2108258922 @default.
• W2023563658 cites W2122718353 @default.
• W2023563658 cites W2173520866 @default.
• W2023563658 cites W2314940363 @default.
• W2023563658 cites W2410835544 @default.
• W2023563658 cites W2470869994 @default.
• W2023563658 cites W2603909816 @default.
• W2023563658 cites W3099983495 @default.
• W2023563658 cites W3103744160 @default.
• W2023563658 cites W600708032 @default.
• W2023563658 doi "https://doi.org/10.1254/jjp.45.203" @default.
• W2023563658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2830423" @default.
• W2023563658 hasPublicationYear "1987" @default.
• W2023563658 type Work @default.
• W2023563658 sameAs 2023563658 @default.
• W2023563658 citedByCount "9" @default.
• W2023563658 crossrefType "journal-article" @default.
• W2023563658 hasAuthorship W2023563658A5022043062 @default.
• W2023563658 hasAuthorship W2023563658A5032673230 @default.
• W2023563658 hasAuthorship W2023563658A5037866444 @default.
• W2023563658 hasBestOaLocation W20235636581 @default.
• W2023563658 hasConcept C126322002 @default.
• W2023563658 hasConcept C134018914 @default.
• W2023563658 hasConcept C178790620 @default.
• W2023563658 hasConcept C181199279 @default.
• W2023563658 hasConcept C185592680 @default.
• W2023563658 hasConcept C2775891158 @default.
• W2023563658 hasConcept C2776991684 @default.
• W2023563658 hasConcept C2777658833 @default.
• W2023563658 hasConcept C2778043224 @default.
• W2023563658 hasConcept C2779066535 @default.
• W2023563658 hasConcept C2781212610 @default.
• W2023563658 hasConcept C29688787 @default.
• W2023563658 hasConcept C519063684 @default.
• W2023563658 hasConcept C55493867 @default.
• W2023563658 hasConcept C62826618 @default.
• W2023563658 hasConcept C71924100 @default.
• W2023563658 hasConcept C86803240 @default.
• W2023563658 hasConceptScore W2023563658C126322002 @default.
• W2023563658 hasConceptScore W2023563658C134018914 @default.
• W2023563658 hasConceptScore W2023563658C178790620 @default.
• W2023563658 hasConceptScore W2023563658C181199279 @default.
• W2023563658 hasConceptScore W2023563658C185592680 @default.
• W2023563658 hasConceptScore W2023563658C2775891158 @default.
• W2023563658 hasConceptScore W2023563658C2776991684 @default.
• W2023563658 hasConceptScore W2023563658C2777658833 @default.
• W2023563658 hasConceptScore W2023563658C2778043224 @default.
• W2023563658 hasConceptScore W2023563658C2779066535 @default.
• W2023563658 hasConceptScore W2023563658C2781212610 @default.
• W2023563658 hasConceptScore W2023563658C29688787 @default.
• W2023563658 hasConceptScore W2023563658C519063684 @default.
• W2023563658 hasConceptScore W2023563658C55493867 @default.
• W2023563658 hasConceptScore W2023563658C62826618 @default.
• W2023563658 hasConceptScore W2023563658C71924100 @default.
• W2023563658 hasConceptScore W2023563658C86803240 @default.
• W2023563658 hasIssue "2" @default.
• W2023563658 hasLocation W20235636581 @default.
• W2023563658 hasLocation W20235636582 @default.
• W2023563658 hasOpenAccess W2023563658 @default.
• W2023563658 hasPrimaryLocation W20235636581 @default.
• W2023563658 hasRelatedWork W129740544 @default.
• W2023563658 hasRelatedWork W2023563658 @default.
• W2023563658 hasRelatedWork W2029339326 @default.
• W2023563658 hasRelatedWork W2065741666 @default.
• W2023563658 hasRelatedWork W2078199047 @default.
• W2023563658 hasRelatedWork W2086892519 @default.
• W2023563658 hasRelatedWork W2148282970 @default.
• W2023563658 hasRelatedWork W2336322180 @default.
• W2023563658 hasRelatedWork W2419598879 @default.
• W2023563658 hasRelatedWork W4238782969 @default.

• next