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• W2023563864 abstract "We investigated the possible effect of the 3111T/C CLOCK gene polymorphism on sleep disorders in a sample of 620 patients affected by major depressive disorder (MDD) and bipolar disorder (BP). We detected a significantly higher recurrence of initial (P = 0.0001), middle (P = 0.0009), and early (P = 0.0008) insomnia in homozygotes for the C variant and a similar trend concerning decreased need of sleep in BP (P = 0.0074). Other demographic and clinical features were found not related with CLOCK polymorphisms. This preliminary observation leads to hypothesize a possible involvement of the CLOCK gene polymorphism in the sleep disregulations in MDD and BP." @default.
• W2023563864 created "2016-06-24" @default.
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• W2023563864 date "2003-05-29" @default.
• W2023563864 modified "2023-10-18" @default.
• W2023563864 title "Genetic dissection of psychopathological symptoms: Insomnia in mood disorders and <i>CLOCK</i> gene polymorphism" @default.
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• W2023563864 doi "https://doi.org/10.1002/ajmg.b.20053" @default.
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