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• W2023567520 endingPage "329" @default.
• W2023567520 startingPage "325" @default.
• W2023567520 abstract "Medial prefrontal cortex (MPFC) is one of the brain regions which play an important role in emotional behaviors. The purpose of the present study was to evaluate the role of 5HT1A and 5HT1B receptors of the MPFC in modulation of anxiety behaviors in rats. The elevated plus maze (EPM) which is a useful test to investigate the effects of anxiogenic or anxiolytic drugs in rodents, was used. Bilateral intra-MPFC administration of 5HT1A receptor agonist, 8-OH-DPAT (5, 10, and 50 ng/rat) decreased the percentages of open arm time (OAT%) and open arm entries (OAE%), indicating an anxiogenic response. Moreover, administration of 5HT1A receptor antagonist, NAN-190 (0.25, 0.5, and 1 μg/rat) significantly increased OAT% and OAE%. Pre-treatment administration of NAN-190 (0.5 μg/rat), which was injected into the MPFC, reversed the anxiogenic effects of 8-OH-DPAT (5, 10, and 50 ng/rat). Intra-MPFC microinjection of 5HT1B receptor agonist, CGS-12066A (0.25, 0.5, and 1 μg/rat) significantly decreased OAT% and OAE%, without any change in locomotor activity, indicating an anxiogenic effect. However, injection of 5HT1B receptor antagonist, SB-224289 (0.5, 1, and 2 μg/rat) into the MPFC showed no significant effect. In conclusion, these findings suggest that 5HT1A and 5HT1B receptors of the MPFC region modulate anxiogenic-like behaviors in rats." @default.
• W2023567520 created "2016-06-24" @default.
• W2023567520 creator A5041404117 @default.
• W2023567520 creator A5051338046 @default.
• W2023567520 creator A5091533386 @default.
• W2023567520 date "2011-10-01" @default.
• W2023567520 modified "2023-09-26" @default.
• W2023567520 title "5HT1A and 5HT1B receptors of medial prefrontal cortex modulate anxiogenic-like behaviors in rats" @default.
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• W2023567520 doi "https://doi.org/10.1016/j.neulet.2011.09.058" @default.
• W2023567520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21982809" @default.
• W2023567520 hasPublicationYear "2011" @default.
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