Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023570044> ?p ?o ?g. }
- W2023570044 endingPage "1335" @default.
- W2023570044 startingPage "1326" @default.
- W2023570044 abstract "Extracellular ATP formation from ADP and inorganic phosphate, attributed to the activity of a cell surface ATP synthase, has so far only been reported in cultures of some proliferating and tumoral cell lines. We now provide evidence showing the presence of a functionally active ecto-FoF1-ATP synthase on the plasma membrane of normal tissue cells, i.e. isolated rat hepatocytes. Both confocal microscopy and flow cytometry analysis show the presence of subunits of F1 (α/β and γ) and Fo (FoI-PVP(b) and OSCP) moieties of ATP synthase at the surface of rat hepatocytes. This finding is confirmed by immunoblotting analysis of the hepatocyte plasma membrane fraction. The presence of the inhibitor protein IF1 is also detected on the hepatocyte surface. Activity assays show that the ectopic-ATP synthase can work both in the direction of ATP synthesis and hydrolysis. A proton translocation assay shows that both these mechanisms are accompanied by a transient flux of H+ and are inhibited by F1 and Fo-targeting inhibitors. We hypothesise that ecto-FoF1-ATP synthase may control the extracellular ADP/ATP ratio, thus contributing to intracellular pH homeostasis." @default.
- W2023570044 created "2016-06-24" @default.
- W2023570044 creator A5027596459 @default.
- W2023570044 creator A5035825357 @default.
- W2023570044 creator A5049093944 @default.
- W2023570044 creator A5054222859 @default.
- W2023570044 creator A5070240117 @default.
- W2023570044 creator A5074561273 @default.
- W2023570044 date "2008-10-01" @default.
- W2023570044 modified "2023-10-15" @default.
- W2023570044 title "Structural and functional characterization of FoF1-ATP synthase on the extracellular surface of rat hepatocytes" @default.
- W2023570044 cites W150957519 @default.
- W2023570044 cites W1536491546 @default.
- W2023570044 cites W1536720659 @default.
- W2023570044 cites W1586093989 @default.
- W2023570044 cites W1600115166 @default.
- W2023570044 cites W1605194916 @default.
- W2023570044 cites W1877505668 @default.
- W2023570044 cites W1964976203 @default.
- W2023570044 cites W1973950246 @default.
- W2023570044 cites W1974607158 @default.
- W2023570044 cites W1974665228 @default.
- W2023570044 cites W1975243533 @default.
- W2023570044 cites W1985001710 @default.
- W2023570044 cites W1992483696 @default.
- W2023570044 cites W1999557198 @default.
- W2023570044 cites W2000646838 @default.
- W2023570044 cites W2002689911 @default.
- W2023570044 cites W2017774635 @default.
- W2023570044 cites W2021900417 @default.
- W2023570044 cites W2033234176 @default.
- W2023570044 cites W2035775636 @default.
- W2023570044 cites W2041218674 @default.
- W2023570044 cites W2054572692 @default.
- W2023570044 cites W2057600253 @default.
- W2023570044 cites W2065031102 @default.
- W2023570044 cites W2066288680 @default.
- W2023570044 cites W2067888338 @default.
- W2023570044 cites W2071163862 @default.
- W2023570044 cites W2072928113 @default.
- W2023570044 cites W2078769628 @default.
- W2023570044 cites W2084911599 @default.
- W2023570044 cites W2089061471 @default.
- W2023570044 cites W2126830227 @default.
- W2023570044 cites W2127886703 @default.
- W2023570044 cites W2150227713 @default.
- W2023570044 cites W2171879718 @default.
- W2023570044 doi "https://doi.org/10.1016/j.bbabio.2008.08.003" @default.
- W2023570044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18775409" @default.
- W2023570044 hasPublicationYear "2008" @default.
- W2023570044 type Work @default.
- W2023570044 sameAs 2023570044 @default.
- W2023570044 citedByCount "80" @default.
- W2023570044 countsByYear W20235700442012 @default.
- W2023570044 countsByYear W20235700442013 @default.
- W2023570044 countsByYear W20235700442014 @default.
- W2023570044 countsByYear W20235700442015 @default.
- W2023570044 countsByYear W20235700442016 @default.
- W2023570044 countsByYear W20235700442017 @default.
- W2023570044 countsByYear W20235700442018 @default.
- W2023570044 countsByYear W20235700442019 @default.
- W2023570044 countsByYear W20235700442020 @default.
- W2023570044 countsByYear W20235700442021 @default.
- W2023570044 countsByYear W20235700442022 @default.
- W2023570044 crossrefType "journal-article" @default.
- W2023570044 hasAuthorship W2023570044A5027596459 @default.
- W2023570044 hasAuthorship W2023570044A5035825357 @default.
- W2023570044 hasAuthorship W2023570044A5049093944 @default.
- W2023570044 hasAuthorship W2023570044A5054222859 @default.
- W2023570044 hasAuthorship W2023570044A5070240117 @default.
- W2023570044 hasAuthorship W2023570044A5074561273 @default.
- W2023570044 hasBestOaLocation W20235700441 @default.
- W2023570044 hasConcept C112243037 @default.
- W2023570044 hasConcept C119120687 @default.
- W2023570044 hasConcept C12554922 @default.
- W2023570044 hasConcept C141315368 @default.
- W2023570044 hasConcept C171357686 @default.
- W2023570044 hasConcept C181199279 @default.
- W2023570044 hasConcept C185592680 @default.
- W2023570044 hasConcept C191678065 @default.
- W2023570044 hasConcept C202751555 @default.
- W2023570044 hasConcept C23265538 @default.
- W2023570044 hasConcept C2776200302 @default.
- W2023570044 hasConcept C2781142959 @default.
- W2023570044 hasConcept C28406088 @default.
- W2023570044 hasConcept C54355233 @default.
- W2023570044 hasConcept C55493867 @default.
- W2023570044 hasConcept C79879829 @default.
- W2023570044 hasConcept C81885089 @default.
- W2023570044 hasConcept C86803240 @default.
- W2023570044 hasConcept C95444343 @default.
- W2023570044 hasConcept C98539663 @default.
- W2023570044 hasConceptScore W2023570044C112243037 @default.
- W2023570044 hasConceptScore W2023570044C119120687 @default.
- W2023570044 hasConceptScore W2023570044C12554922 @default.
- W2023570044 hasConceptScore W2023570044C141315368 @default.
- W2023570044 hasConceptScore W2023570044C171357686 @default.
- W2023570044 hasConceptScore W2023570044C181199279 @default.