FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023571480> ?p ?o ?g. }

• W2023571480 endingPage "1000" @default.
• W2023571480 startingPage "991" @default.
• W2023571480 abstract "In classical tetrameric voltage-gated ion channels four voltage-sensing domains (VSDs), one from each subunit, control one ion permeation pathway formed by four pore domains. The human Hv1 proton channel has a different architecture, containing a VSD, but lacking a pore domain. Since its location is not known, we searched for the Hv permeation pathway. We find that mutation of the S4 segment's third arginine R211 (R3) compromises proton selectivity, enabling conduction of a metal cation and even of the large organic cation guanidinium, reminiscent of Shaker's omega pore. In the open state, R3 appears to interact with an aspartate (D112) that is situated in the middle of S1 and is unique to Hv channels. The double mutation of both residues further compromises cation selectivity. We propose that membrane depolarization reversibly positions R3 next to D112 in the transmembrane VSD to form the ion selectivity filter in the channel's open conformation." @default.
• W2023571480 created "2016-06-24" @default.
• W2023571480 creator A5064419864 @default.
• W2023571480 creator A5081378606 @default.
• W2023571480 date "2011-12-01" @default.
• W2023571480 modified "2023-10-01" @default.
• W2023571480 title "The Pore of the Voltage-Gated Proton Channel" @default.
• W2023571480 cites W1965191256 @default.
• W2023571480 cites W1967108876 @default.
• W2023571480 cites W1969129798 @default.
• W2023571480 cites W1969708254 @default.
• W2023571480 cites W1983482531 @default.
• W2023571480 cites W1983523125 @default.
• W2023571480 cites W1987382493 @default.
• W2023571480 cites W1998078867 @default.
• W2023571480 cites W2000456276 @default.
• W2023571480 cites W2004933597 @default.
• W2023571480 cites W2008470626 @default.
• W2023571480 cites W2013053709 @default.
• W2023571480 cites W2019998982 @default.
• W2023571480 cites W2022790697 @default.
• W2023571480 cites W2029592445 @default.
• W2023571480 cites W2041836266 @default.
• W2023571480 cites W2042914373 @default.
• W2023571480 cites W2044921719 @default.
• W2023571480 cites W2055633644 @default.
• W2023571480 cites W2063340476 @default.
• W2023571480 cites W2076113078 @default.
• W2023571480 cites W2081912246 @default.
• W2023571480 cites W2086701162 @default.
• W2023571480 cites W2087122819 @default.
• W2023571480 cites W2087700141 @default.
• W2023571480 cites W2088484448 @default.
• W2023571480 cites W2090091933 @default.
• W2023571480 cites W2103566186 @default.
• W2023571480 cites W2120772351 @default.
• W2023571480 cites W2136291641 @default.
• W2023571480 cites W2148368846 @default.
• W2023571480 cites W2155936520 @default.
• W2023571480 cites W2161832860 @default.
• W2023571480 cites W2170720883 @default.
• W2023571480 cites W2411636689 @default.
• W2023571480 doi "https://doi.org/10.1016/j.neuron.2011.11.014" @default.
• W2023571480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3244940" @default.
• W2023571480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22196334" @default.
• W2023571480 hasPublicationYear "2011" @default.
• W2023571480 type Work @default.
• W2023571480 sameAs 2023571480 @default.
• W2023571480 citedByCount "60" @default.
• W2023571480 countsByYear W20235714802012 @default.
• W2023571480 countsByYear W20235714802013 @default.
• W2023571480 countsByYear W20235714802014 @default.
• W2023571480 countsByYear W20235714802015 @default.
• W2023571480 countsByYear W20235714802016 @default.
• W2023571480 countsByYear W20235714802017 @default.
• W2023571480 countsByYear W20235714802018 @default.
• W2023571480 countsByYear W20235714802019 @default.
• W2023571480 countsByYear W20235714802020 @default.
• W2023571480 countsByYear W20235714802021 @default.
• W2023571480 countsByYear W20235714802022 @default.
• W2023571480 countsByYear W20235714802023 @default.
• W2023571480 crossrefType "journal-article" @default.
• W2023571480 hasAuthorship W2023571480A5064419864 @default.
• W2023571480 hasAuthorship W2023571480A5081378606 @default.
• W2023571480 hasBestOaLocation W20235714801 @default.
• W2023571480 hasConcept C104292427 @default.
• W2023571480 hasConcept C104317684 @default.
• W2023571480 hasConcept C118792377 @default.
• W2023571480 hasConcept C118892022 @default.
• W2023571480 hasConcept C121332964 @default.
• W2023571480 hasConcept C12554922 @default.
• W2023571480 hasConcept C161790260 @default.
• W2023571480 hasConcept C170493617 @default.
• W2023571480 hasConcept C178790620 @default.
• W2023571480 hasConcept C181911157 @default.
• W2023571480 hasConcept C185592680 @default.
• W2023571480 hasConcept C198394728 @default.
• W2023571480 hasConcept C24530287 @default.
• W2023571480 hasConcept C2779421379 @default.
• W2023571480 hasConcept C37088560 @default.
• W2023571480 hasConcept C4141045 @default.
• W2023571480 hasConcept C41625074 @default.
• W2023571480 hasConcept C50254741 @default.
• W2023571480 hasConcept C50670333 @default.
• W2023571480 hasConcept C50952357 @default.
• W2023571480 hasConcept C537181965 @default.
• W2023571480 hasConcept C54516573 @default.
• W2023571480 hasConcept C55493867 @default.
• W2023571480 hasConcept C62520636 @default.
• W2023571480 hasConcept C86803240 @default.
• W2023571480 hasConcept C99975950 @default.
• W2023571480 hasConceptScore W2023571480C104292427 @default.
• W2023571480 hasConceptScore W2023571480C104317684 @default.
• W2023571480 hasConceptScore W2023571480C118792377 @default.
• W2023571480 hasConceptScore W2023571480C118892022 @default.
• W2023571480 hasConceptScore W2023571480C121332964 @default.
• W2023571480 hasConceptScore W2023571480C12554922 @default.
• W2023571480 hasConceptScore W2023571480C161790260 @default.

• next