FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023572006> ?p ?o ?g. }

• W2023572006 endingPage "261" @default.
• W2023572006 startingPage "252" @default.
• W2023572006 abstract "Tumor microenvironment is a complex and highly dynamic milieu that provides very important clues on tumor development and progression mechanisms. Tumor-associated endothelial cells play a key role in stroma organization. They achieve tumor angiogenesis, a formation of tumor-associated (angiogenic) vessels mainly through sprouting from locally preexisting vessels and/or recruitment of bone marrow-derived endothelial progenitor cells. This process participates to supply nutritional support and oxygen to the growing tumor. Endothelial cells constitute the interface between circulating blood cells, tumor cells and the extracellular matrix, thereby controlling leukocyte recruitment, tumor cell behavior and metastasis formation. Hypoxia, a critical parameter of the tumor microenvironment, controls endothelial/tumor cell interactions and is the key to tumor angiogenesis development. Under hypoxic stress, tumor cells produce factors that promote angiogenesis, vasculogenesis, tumor cell motility, metastasis and cancer stem cell selection. Targeting tumor vessels is a therapeutic strategy that has lately been fast evolving from antiangiogenesis to vessel normalization as discussed in this review. We shall focus on the pivotal role of endothelial cells within the tumor microenvironment, the specific features and the part played by circulating endothelial precursors cells. Attention is stressed on their recruitment to the tumor site and their role in tumor angiogenesis where they are submitted to miRNAs-mediated de/regulation. Here the compensation of the tumor deregulated angiogenic miRNAs – angiomiRs - is emphasized as a potential therapeutic approach. The strategy is to over express anti-angiomiRs in the tumor angiogenesis site upon selective delivery by precursor endothelial cells as miRs carriers." @default.
• W2023572006 created "2016-06-24" @default.
• W2023572006 creator A5040712491 @default.
• W2023572006 creator A5044203787 @default.
• W2023572006 creator A5056751083 @default.
• W2023572006 creator A5057446036 @default.
• W2023572006 creator A5058317825 @default.
• W2023572006 creator A5058831220 @default.
• W2023572006 creator A5070523486 @default.
• W2023572006 date "2012-05-01" @default.
• W2023572006 modified "2023-09-24" @default.
• W2023572006 title "Hypoxia control to normalize pathologic angiogenesis: Potential role for endothelial precursor cells and miRNAs regulation" @default.
• W2023572006 cites W1485875137 @default.
• W2023572006 cites W1495287184 @default.
• W2023572006 cites W1969592877 @default.
• W2023572006 cites W1969614398 @default.
• W2023572006 cites W1971276126 @default.
• W2023572006 cites W1972111686 @default.
• W2023572006 cites W1972551831 @default.
• W2023572006 cites W1974195547 @default.
• W2023572006 cites W1975375912 @default.
• W2023572006 cites W1975807306 @default.
• W2023572006 cites W1979679866 @default.
• W2023572006 cites W1981149366 @default.
• W2023572006 cites W1981612052 @default.
• W2023572006 cites W1983763042 @default.
• W2023572006 cites W1986630370 @default.
• W2023572006 cites W1987670809 @default.
• W2023572006 cites W1992112921 @default.
• W2023572006 cites W1992767716 @default.
• W2023572006 cites W1993016882 @default.
• W2023572006 cites W1995168398 @default.
• W2023572006 cites W1997939286 @default.
• W2023572006 cites W1998166046 @default.
• W2023572006 cites W2000827695 @default.
• W2023572006 cites W2001295759 @default.
• W2023572006 cites W2001849947 @default.
• W2023572006 cites W2003476770 @default.
• W2023572006 cites W2003670869 @default.
• W2023572006 cites W2004150448 @default.
• W2023572006 cites W2005058175 @default.
• W2023572006 cites W2005233976 @default.
• W2023572006 cites W2006202974 @default.
• W2023572006 cites W2010402627 @default.
• W2023572006 cites W2013946089 @default.
• W2023572006 cites W2014722961 @default.
• W2023572006 cites W2015681531 @default.
• W2023572006 cites W2017358009 @default.
• W2023572006 cites W2020118286 @default.
• W2023572006 cites W2021381932 @default.
• W2023572006 cites W2022181032 @default.
• W2023572006 cites W2025635382 @default.
• W2023572006 cites W2035615893 @default.
• W2023572006 cites W2040075459 @default.
• W2023572006 cites W2042396951 @default.
• W2023572006 cites W2042452069 @default.
• W2023572006 cites W2043083650 @default.
• W2023572006 cites W2047470479 @default.
• W2023572006 cites W2048577371 @default.
• W2023572006 cites W2048829586 @default.
• W2023572006 cites W2049016944 @default.
• W2023572006 cites W2049391622 @default.
• W2023572006 cites W2053702192 @default.
• W2023572006 cites W2055009621 @default.
• W2023572006 cites W2057241633 @default.
• W2023572006 cites W2058402992 @default.
• W2023572006 cites W2059888416 @default.
• W2023572006 cites W2062594120 @default.
• W2023572006 cites W2066121965 @default.
• W2023572006 cites W2068707753 @default.
• W2023572006 cites W2071155689 @default.
• W2023572006 cites W2074991531 @default.
• W2023572006 cites W2076704022 @default.
• W2023572006 cites W2081107312 @default.
• W2023572006 cites W2081633887 @default.
• W2023572006 cites W2084740377 @default.
• W2023572006 cites W2090034342 @default.
• W2023572006 cites W2090886213 @default.
• W2023572006 cites W2098888745 @default.
• W2023572006 cites W2100263631 @default.
• W2023572006 cites W2101680696 @default.
• W2023572006 cites W2102526923 @default.
• W2023572006 cites W2104146201 @default.
• W2023572006 cites W2104229067 @default.
• W2023572006 cites W2104300873 @default.
• W2023572006 cites W2108984461 @default.
• W2023572006 cites W2109341154 @default.
• W2023572006 cites W2109622275 @default.
• W2023572006 cites W2119013116 @default.
• W2023572006 cites W2119492915 @default.
• W2023572006 cites W2119897756 @default.
• W2023572006 cites W2121238553 @default.
• W2023572006 cites W2124784163 @default.
• W2023572006 cites W2133521971 @default.
• W2023572006 cites W2134792081 @default.
• W2023572006 cites W2136023563 @default.
• W2023572006 cites W2139128338 @default.
• W2023572006 cites W2140882198 @default.

• next