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• W2023573908 abstract "Nurr1 is an orphan nuclear receptor required for the postspecification differentiation and maintenance of the ventral midbrain dopaminergic neurons that are lost in Parkinson’s disease. In an effort to understand how the action of Nurr1 is regulated, we screened for and identified a new Nurr1-interacting protein, NuIP, that potentiates the transcriptional activity of Nurr1 and contains several protein motifs, suggesting a role in mediating signaling transduction. Herein, we review NuIP’s discovery and functions and propose a strategy to identify small molecules to augment Nurr1 activity through its interaction with NuIP. We speculate that drugs developed to modulate this pathway may have relevance for the treatment of Parkinson’s disease." @default.
• W2023573908 created "2016-06-24" @default.
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• W2023573908 date "2009-03-01" @default.
• W2023573908 modified "2023-09-27" @default.
• W2023573908 title "Potential of Nurr1 interactions to disclose new Parkinson’s therapeutics" @default.
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• W2023573908 doi "https://doi.org/10.2217/14796708.4.2.161" @default.
• W2023573908 hasPublicationYear "2009" @default.
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