FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023574032> ?p ?o ?g. }

• W2023574032 endingPage "13" @default.
• W2023574032 startingPage "7" @default.
• W2023574032 abstract "To investigate the presence of the fibronectin isoform containing the extradomain B (B-FN), a marker-protein of angiogenesis, in surgically excised human choroidal neovascular membranes (CNVM) to evaluate whether B-FN could be used as a therapeutic target for specific antibody-photosensitizer immunoconjugates.Laboratory investigation.The setting was an institutional practice. The study population consisted of 15 eyes (15 patients) with CNVM undergoing membrane excision (four eyes with age-related macular degeneration, seven with pathologic myopia and four with multifocal choroiditis). The control group consisted of eight eye bank eyes (four subjects) without choroidal neovascularization. Light microscopic immunohistochemistry on cryostat sections of tissues was obtained. B-FN was detected by a human recombinant antibody, CGS-1, and compared with immunostaining for endothelial cells with factor VIII-related antigen. The main outcome measure was the presence of CGS-1 positively stained cells or areas of the extracellular matrix. Staining of CGS-1 was scored on a scale from 0 to 3.Fourteen of 15 neovascular membranes stained strongly with CGS-1 (score 2 or 3). One membrane from a patient with pathologic myopia was negatively stained (score 0). CGS-1 positive staining was detected around endothelial cells and in the extracellular matrix of CNVMs. The retina of eyes without choroidal neovascularization was negative with CGS-1 in all eight donor eyes, while the choroid contained some weakly CGS-1 positive cells (score 0 and 1, respectively).The extradomain B is abundantly expressed in CNVMs, but its expression is more restricted in eyes harboring no apparent choroidal neovascularization. In the future, B-FN might serve as a target for the delivery of antibody-photosensitizer immunoconjugates to newly developed vessels to enhance the selectivity of photodynamic therapy." @default.
• W2023574032 created "2016-06-24" @default.
• W2023574032 creator A5009610726 @default.
• W2023574032 creator A5015367159 @default.
• W2023574032 creator A5016656441 @default.
• W2023574032 creator A5020168745 @default.
• W2023574032 creator A5049485275 @default.
• W2023574032 creator A5071486343 @default.
• W2023574032 creator A5078956448 @default.
• W2023574032 creator A5088959959 @default.
• W2023574032 creator A5091640628 @default.
• W2023574032 date "2003-01-01" @default.
• W2023574032 modified "2023-10-03" @default.
• W2023574032 title "Expression of extradomain-B–containing fibronectin in subretinal choroidal neovascular membranes" @default.
• W2023574032 cites W1480779622 @default.
• W2023574032 cites W1485340008 @default.
• W2023574032 cites W1581487302 @default.
• W2023574032 cites W1601975653 @default.
• W2023574032 cites W1991862591 @default.
• W2023574032 cites W2000288150 @default.
• W2023574032 cites W2000741532 @default.
• W2023574032 cites W2004625262 @default.
• W2023574032 cites W2006343663 @default.
• W2023574032 cites W2009507555 @default.
• W2023574032 cites W2012390831 @default.
• W2023574032 cites W2030495747 @default.
• W2023574032 cites W2033726093 @default.
• W2023574032 cites W2037538204 @default.
• W2023574032 cites W2046044320 @default.
• W2023574032 cites W2058635875 @default.
• W2023574032 cites W2065471162 @default.
• W2023574032 cites W2066188919 @default.
• W2023574032 cites W2083684074 @default.
• W2023574032 cites W2090792345 @default.
• W2023574032 cites W2115420079 @default.
• W2023574032 cites W2135712099 @default.
• W2023574032 cites W2152699331 @default.
• W2023574032 cites W2153012997 @default.
• W2023574032 cites W2165539456 @default.
• W2023574032 cites W2166269000 @default.
• W2023574032 cites W24809142 @default.
• W2023574032 cites W2889092143 @default.
• W2023574032 cites W29053622 @default.
• W2023574032 cites W4246295494 @default.
• W2023574032 doi "https://doi.org/10.1016/s0002-9394(02)01839-1" @default.
• W2023574032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12504690" @default.
• W2023574032 hasPublicationYear "2003" @default.
• W2023574032 type Work @default.
• W2023574032 sameAs 2023574032 @default.
• W2023574032 citedByCount "14" @default.
• W2023574032 countsByYear W20235740322015 @default.
• W2023574032 countsByYear W20235740322020 @default.
• W2023574032 crossrefType "journal-article" @default.
• W2023574032 hasAuthorship W2023574032A5009610726 @default.
• W2023574032 hasAuthorship W2023574032A5015367159 @default.
• W2023574032 hasAuthorship W2023574032A5016656441 @default.
• W2023574032 hasAuthorship W2023574032A5020168745 @default.
• W2023574032 hasAuthorship W2023574032A5049485275 @default.
• W2023574032 hasAuthorship W2023574032A5071486343 @default.
• W2023574032 hasAuthorship W2023574032A5078956448 @default.
• W2023574032 hasAuthorship W2023574032A5088959959 @default.
• W2023574032 hasAuthorship W2023574032A5091640628 @default.
• W2023574032 hasConcept C118487528 @default.
• W2023574032 hasConcept C126322002 @default.
• W2023574032 hasConcept C142724271 @default.
• W2023574032 hasConcept C169760540 @default.
• W2023574032 hasConcept C189165786 @default.
• W2023574032 hasConcept C204232928 @default.
• W2023574032 hasConcept C2776403814 @default.
• W2023574032 hasConcept C2776694393 @default.
• W2023574032 hasConcept C2777093970 @default.
• W2023574032 hasConcept C2778257484 @default.
• W2023574032 hasConcept C2778271429 @default.
• W2023574032 hasConcept C2780394083 @default.
• W2023574032 hasConcept C2781242345 @default.
• W2023574032 hasConcept C2781325737 @default.
• W2023574032 hasConcept C2781359195 @default.
• W2023574032 hasConcept C2908647359 @default.
• W2023574032 hasConcept C4224716 @default.
• W2023574032 hasConcept C71924100 @default.
• W2023574032 hasConcept C74864618 @default.
• W2023574032 hasConcept C86492073 @default.
• W2023574032 hasConcept C86803240 @default.
• W2023574032 hasConcept C95444343 @default.
• W2023574032 hasConcept C99454951 @default.
• W2023574032 hasConceptScore W2023574032C118487528 @default.
• W2023574032 hasConceptScore W2023574032C126322002 @default.
• W2023574032 hasConceptScore W2023574032C142724271 @default.
• W2023574032 hasConceptScore W2023574032C169760540 @default.
• W2023574032 hasConceptScore W2023574032C189165786 @default.
• W2023574032 hasConceptScore W2023574032C204232928 @default.
• W2023574032 hasConceptScore W2023574032C2776403814 @default.
• W2023574032 hasConceptScore W2023574032C2776694393 @default.
• W2023574032 hasConceptScore W2023574032C2777093970 @default.
• W2023574032 hasConceptScore W2023574032C2778257484 @default.
• W2023574032 hasConceptScore W2023574032C2778271429 @default.
• W2023574032 hasConceptScore W2023574032C2780394083 @default.
• W2023574032 hasConceptScore W2023574032C2781242345 @default.

• next