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- W2023574043 abstract "A NUMBER of recent reports have dealt with inhibition of methylation in Streptomyces aureofaciens. Strains of this organism which normally synthesize chlortetracycline can be directed toward the production of the 6-demethyl analogue by adding a number of compounds to the medium. Such compounds have included a variety of sulphonamides1,2 and aminopterin3 which act as inhibitors of folic acid mediated C6-methylation. In addition ethionine3–5, and to some extent D-methionine5, when added to the medium have also caused 6-demethylchlortetracycline production presumably by acting as antagonists of L-methionine, the normal source of the 6 methyl group6." @default.
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- W2023574043 date "1964-01-01" @default.
- W2023574043 modified "2023-09-25" @default.
- W2023574043 title "Effect of Norleucine on the Synthesis of Demethylchlortetracycline by Streptomyces aureofaciens" @default.
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- W2023574043 doi "https://doi.org/10.1038/201190a0" @default.
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