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• W2023574426 startingPage "475" @default.
• W2023574426 abstract "To study the immunomodulative activity caused by bovine leukemia virus envelope (BLV Env) peptide, sheep were immunized with two kinds of Th-epitope peptides, peptide 98 (BLV Env 98-117), and 61 (BLV Env 61-78). Four of eight immunized sheep showed specific proliferative responses against both of the peptide stimulations. To characterize the cells responding to the peptides, peptide-specific cells were established from the responding sheep by the continuous stimulation of peripheral blood mononuclear cells (PBMCs) with either peptide 98 or 61 in vitro. The peptide 98-specific cells consisted of CD4-positive cells, whereas the peptide 61-specific cells consisted of CD8-positive cells and MHC class II-positive cells. In addition, cytokine profile analysis indicated that the peptide 98-stimulated cells expressed IFN-γ but not IL-10, although the peptide 61-stimulated cells expressed IL-10 but not IFN-γ. These results show that BLV envelope peptides 98 and 61 can modulate immune responses of sheep lymphocytes in different ways and may contribute to the pathogenesis of BLV infection." @default.
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• W2023574426 date "1999-01-01" @default.
• W2023574426 modified "2023-10-03" @default.
• W2023574426 title "Characterization of Immune Responses Caused by Bovine Leukemia Virus Envelope Peptides in Sheep" @default.
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• W2023574426 doi "https://doi.org/10.1292/jvms.61.475" @default.
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