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• W2023576285 startingPage "116" @default.
• W2023576285 abstract "Many intracellular functions have been attributed to resveratrol, a polyphenolic phytoalexin found in grapes and in other plants. Here, we show that resveratrol induces the expression of the transcription factor Egr-1 in human embryonic kidney cells. Using a chromosomally embedded Egr-1-responsive reporter gene, we show that the Egr-1 activity was significantly elevated in resveratrol-treated cells, indicating that the newly synthesized Egr-1 protein was biologically active. Stimulus-transcription coupling leading to the resveratrol-induced upregulation of Egr-1 expression and activity requires the protein kinases Raf and extracellular signal-regulated protein kinase ERK, while MAP kinase phosphatase-1 functions as a nuclear shut-off device that interrupts the signaling cascade connecting resveratrol stimulation with enhanced Egr-1 expression. On the transcriptional level, Elk-1, a key transcriptional regulator of serum response element-driven gene transcription, connects the intracellular signaling cascade elicited by resveratrol with transcription of the Egr-1 gene. These data were corroborated by the observation that stimulation of the cells with resveratrol increased the transcriptional activation potential of Elk-1. The SRE as well as the GC-rich DNA binding site of Egr-1 function as resveratrol-responsive elements. Thus, resveratrol regulates gene transcription via activation of the stimulus-regulated protein kinases Raf and ERK and the stimulus-responsive transcription factors TCF and Egr-1." @default.
• W2023576285 created "2016-06-24" @default.
• W2023576285 creator A5033376044 @default.
• W2023576285 creator A5077237302 @default.
• W2023576285 creator A5083795582 @default.
• W2023576285 date "2015-03-01" @default.
• W2023576285 modified "2023-10-02" @default.
• W2023576285 title "Resveratrol upregulates Egr-1 expression and activity involving extracellular signal-regulated protein kinase and ternary complex factors" @default.
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• W2023576285 doi "https://doi.org/10.1016/j.yexcr.2015.01.013" @default.
• W2023576285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25645941" @default.
• W2023576285 hasPublicationYear "2015" @default.
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