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- W2023579681 abstract "The drug resistance due to the overexpression of MDR1 is a major obstacle to a successful chemotherapy of human malignancies. In order to survey the mechanisms of regulation of MDR1 the expression of various tumor characteristics were studied in 62 different solid human tumor types growing subcutaneously in nude mice (xenografts). Northern and slot blot analysis revealed a statistical significant correlation (P In conclusion, the association of MDR1, MDR3 and GST-π with oncogenes (k-ras) as well as with other tumor characteristics (CEA, p53) implies the involvement of the regulation of these resistance factors in complex molecular events during the progression of human cancers." @default.
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- W2023579681 date "1995-11-01" @default.
- W2023579681 modified "2023-09-27" @default.
- W2023579681 title "105 Correlation between expression of MDR1, GST-π, K-RAS, MDR3, CEA in human tumor xenografts" @default.
- W2023579681 doi "https://doi.org/10.1016/0959-8049(95)95360-i" @default.
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