Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023581551> ?p ?o ?g. }
- W2023581551 endingPage "2292" @default.
- W2023581551 startingPage "2281" @default.
- W2023581551 abstract "Abstract Group II introns are naturally occurring ribozymes in plants, fungi, bacteria, and lower eukaryotes that undergo a fascinating array of reactions. These large molecular machines with a size ranging between 600 and 2500 nucleotides are self‐splicing introns also capable of reinserting themselves into RNA or DNA, thus making them mobile genetic elements. The structural information available on group II intron ribozymes is very scarce. So far, only one crystal structure and one NMR solution structure of two domains located in the catalytic core are available. For proper folding and function, each intron requires specific concentrations of monovalent and divalent metal ions. Although most of these metal ions are used for charge screening, some are bound to distinct sites as has been shown by hydrolytic cleavage experiments. These specifically bound ions are crucial for tertiary contact formation and catalysis. This review will discuss the different metal‐ion requirements of self‐splicing group II introns, the available structural data and information on the binding location and affinity of metal ions, as well as the methods applied to investigate the metal‐ion binding properties of these large RNAs. Due to the size of these introns, the richness of local structures, the catalytic versatility and the involvement of metal ions in all of the above‐mentioned aspects, group II introns are an ideal target to be studied by combined means from the fields of Biochemistry, Molecular Biology, Analytical, and (Bio)Inorganic Chemistry. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)" @default.
- W2023581551 created "2016-06-24" @default.
- W2023581551 creator A5021200399 @default.
- W2023581551 date "2005-06-01" @default.
- W2023581551 modified "2023-10-12" @default.
- W2023581551 title "Group II Intron Ribozymes and Metal Ions – A Delicate Relationship" @default.
- W2023581551 cites W1158930877 @default.
- W2023581551 cites W139107379 @default.
- W2023581551 cites W1467135814 @default.
- W2023581551 cites W1489623410 @default.
- W2023581551 cites W1501232407 @default.
- W2023581551 cites W1503876631 @default.
- W2023581551 cites W1527224736 @default.
- W2023581551 cites W1571856798 @default.
- W2023581551 cites W1579647280 @default.
- W2023581551 cites W1588543465 @default.
- W2023581551 cites W1657937336 @default.
- W2023581551 cites W1963923989 @default.
- W2023581551 cites W1965074632 @default.
- W2023581551 cites W1965423166 @default.
- W2023581551 cites W1966708748 @default.
- W2023581551 cites W1968282235 @default.
- W2023581551 cites W1968723036 @default.
- W2023581551 cites W1972561495 @default.
- W2023581551 cites W1972570758 @default.
- W2023581551 cites W1972681980 @default.
- W2023581551 cites W1972708527 @default.
- W2023581551 cites W1973598980 @default.
- W2023581551 cites W1974066635 @default.
- W2023581551 cites W1975260126 @default.
- W2023581551 cites W1975649825 @default.
- W2023581551 cites W1979171323 @default.
- W2023581551 cites W1980410097 @default.
- W2023581551 cites W1983359810 @default.
- W2023581551 cites W1986412619 @default.
- W2023581551 cites W1989250056 @default.
- W2023581551 cites W1995427534 @default.
- W2023581551 cites W1997880480 @default.
- W2023581551 cites W1999238690 @default.
- W2023581551 cites W1999404678 @default.
- W2023581551 cites W2000861398 @default.
- W2023581551 cites W2002195659 @default.
- W2023581551 cites W2002653581 @default.
- W2023581551 cites W2002664542 @default.
- W2023581551 cites W2003906424 @default.
- W2023581551 cites W2004927896 @default.
- W2023581551 cites W2005665960 @default.
- W2023581551 cites W2007099197 @default.
- W2023581551 cites W2007143725 @default.
- W2023581551 cites W2010683202 @default.
- W2023581551 cites W2011588721 @default.
- W2023581551 cites W2011722931 @default.
- W2023581551 cites W2014601660 @default.
- W2023581551 cites W2015677193 @default.
- W2023581551 cites W2015749911 @default.
- W2023581551 cites W2019136531 @default.
- W2023581551 cites W2021333801 @default.
- W2023581551 cites W2021920164 @default.
- W2023581551 cites W2022289189 @default.
- W2023581551 cites W2023651073 @default.
- W2023581551 cites W2026644995 @default.
- W2023581551 cites W2026817175 @default.
- W2023581551 cites W2027506232 @default.
- W2023581551 cites W2028034245 @default.
- W2023581551 cites W2030013621 @default.
- W2023581551 cites W2030219041 @default.
- W2023581551 cites W2035546741 @default.
- W2023581551 cites W2036400318 @default.
- W2023581551 cites W2041331047 @default.
- W2023581551 cites W2042307087 @default.
- W2023581551 cites W2042441128 @default.
- W2023581551 cites W2043356161 @default.
- W2023581551 cites W2043504820 @default.
- W2023581551 cites W2043810954 @default.
- W2023581551 cites W2044020586 @default.
- W2023581551 cites W2044247083 @default.
- W2023581551 cites W2046606379 @default.
- W2023581551 cites W2047683652 @default.
- W2023581551 cites W2048508714 @default.
- W2023581551 cites W2052057621 @default.
- W2023581551 cites W2052946180 @default.
- W2023581551 cites W2054010580 @default.
- W2023581551 cites W2054109341 @default.
- W2023581551 cites W2054613021 @default.
- W2023581551 cites W2055150076 @default.
- W2023581551 cites W2055919409 @default.
- W2023581551 cites W2056412942 @default.
- W2023581551 cites W2056975726 @default.
- W2023581551 cites W2057850636 @default.
- W2023581551 cites W2058897995 @default.
- W2023581551 cites W2061118962 @default.
- W2023581551 cites W2061434726 @default.
- W2023581551 cites W2065616187 @default.
- W2023581551 cites W2070286677 @default.
- W2023581551 cites W2071549620 @default.
- W2023581551 cites W2071780987 @default.
- W2023581551 cites W2075080060 @default.
- W2023581551 cites W2075227252 @default.