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- W2023581956 abstract "<dm:abstracts xmlns:dm=http://www.elsevier.com/xml/dm/dtd><ce:abstract xmlns:ce=http://www.elsevier.com/xml/common/dtd id=abs0010 view=all class=author><ce:section-title id=sect0005>Résumé</ce:section-title><ce:abstract-sec id=abst0005 view=all><ce:simple-para id=spar0005 view=all>La prégabaline n’est pas connue pour induire un parkinsonisme, un seul cas est publié dans la littérature. Dans ce travail, nous rapportons le deuxième cas de Parkinson induit par ce médicament chez une patiente âgée de 58 ans traitée depuis 3 ans à 600<ce:hsp sp=0.25/>mg par jour initialement puis à une dose réduite à 300 mg par jour devant l’apparition de secousses myocloniques et surtout d’une prise de poids. Elle est suivie régulièrement par un neurologue qui constate l’apparition d’un syndrome parkinsonien dont l’asymétrie du tableau clinique fait évoquer une maladie de Parkinson idiopathique mais la tomoscintigraphie des noyaux gris centraux à l’ioflupane–iode 123 (DATSCAN) est normale et l’imagerie par résonance magnétique (IRM) encéphalique ne retrouve qu’une leucopathie banale. Seul l’arrêt de la prégabaline a permis une régression totale du tableau clinique.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:abstract xmlns:ce=http://www.elsevier.com/xml/common/dtd id=abs0005 xml:lang=en view=all class=author><ce:section-title id=sect0010>Summary</ce:section-title><ce:abstract-sec id=abst0010 view=all><ce:simple-para id=spar0010 view=all>Pregabalin is not known to induce parkinsonism, one single case is published in the literature. In this work, we report the second case of parkinsonism-induced by this drug in a 58-year old woman initially dosed at 600<ce:hsp sp=0.25/>mg daily for 3 years which was reduced to 300<ce:hsp sp=0.25/>mg daily after the onset of myoclonic jerks and especially because of a weight gain. She is regularly monitored by a neurologist who notes the onset of a parkinsonian syndrome whose asymmetry clinical picture mimicking an idiopathic Parkinson's disease but positron emission tomography (PET scan) was normal and the brain magnetic resonance imaging MRI found a banal leukopathy. Only the withdrawal of pregabalin conducted to a total improvement of the clinical picture.</ce:simple-para></ce:abstract-sec></ce:abstract></dm:abstracts>" @default.
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- W2023581956 title "Clinical features of AADC-deficient children and therapeutic prospects" @default.
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