FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023582014> ?p ?o ?g. }

• W2023582014 abstract "Previous studies have shown that the glyceride derivative, sn-1,2-isopropylidene-3-decanoyl-glycerol (IpOCOC9), can trigger human leukocyte histamine release. Approximately 25% of the total cellular histamine content is extruded in the presence of 206 microM of IpOCOC9; at 69 microM, however, the secretagogue action of the compound is marginal. The characteristics of the release induced by IpOCOC9 are closely similar to those reportedly recorded at hyperosmolar triggering of basophils with mannitol, and in many respects they also mimic those observed at phorbol ester-induced histamine release. The compound decanoic acid cyclopentyl methylester (DACPME), a structural analogue of IpOCOC9, fails to induce histamine release. IpOCOC9, but not DACPME, stimulates human polymorphonuclear leukocyte cytosolic Ca2+- and phospholipid-dependent histone III-S kinase activity (unpublished observations). The secretagogue action of IpOCOC9 has therefore tentatively, at least partly, been attributed to a direct protein kinase C activation. In the present studies, we examined the influence of IpOCOC9 and DACPME on histamine release triggered by an ensuing exposure to anti-IgE, the calcium ionophore A23187, formyl-methionyl-leucyl-phenylalanine (FMLP), or 4 beta-phorbol 12-myristate 13-acetate (PMA). It is shown that IpOCOC9-treatment of cells results in either enhancement or reduction of the release induced by anti-IgE or by A23187, whereas FMLP-induced release is consistently reduced and PMA-induced release consistently enhanced by such a treatment. Treatment of cells with DACPME enhances but does not reduce anti-IgE-triggered release, whereas FMLP-induced release is not affected. Pretreatment of the cells with other putative protein kinase C activators like PMA, sn-1-oleoyl-2-acetyl-glycerol (OAG), 1,2-dioctanoyl-glycerol (DiC8) or the glycerol derivative sn-1,2-diacetyl-3-decanoyl-glycerol (DiC2OCOC9) affects secretagogue-induced basophil histamine release according to specific patterns similar to but not identical with those recorded for IpOCOC9 and DACPME. Thus, e.g., DiC2OCOC9 consistently reduces but does not enhance anti-IgE-triggered release. These data show that limited structural changes of IpOCOC9 may qualitatively affect its modulating properties in the human basophil histamine release system." @default.
• W2023582014 created "2016-06-24" @default.
• W2023582014 creator A5008633069 @default.
• W2023582014 creator A5029109482 @default.
• W2023582014 creator A5052054829 @default.
• W2023582014 date "1989-01-01" @default.
• W2023582014 modified "2023-09-27" @default.
• W2023582014 title "Modulation of human leukocyte histamine release by sn-1,2-isopropylidene-3-decanoyl-glycerol and decanoic acid cyclopentyl methylester in comparison with effects of synthetic diacylglycerols and a phorbol ester" @default.
• W2023582014 cites W1499632436 @default.
• W2023582014 cites W1519223405 @default.
• W2023582014 cites W1537978981 @default.
• W2023582014 cites W1556549089 @default.
• W2023582014 cites W1562912280 @default.
• W2023582014 cites W1598674360 @default.
• W2023582014 cites W1750204594 @default.
• W2023582014 cites W1963730604 @default.
• W2023582014 cites W1968892796 @default.
• W2023582014 cites W1975299661 @default.
• W2023582014 cites W1980854090 @default.
• W2023582014 cites W1982297215 @default.
• W2023582014 cites W2000528721 @default.
• W2023582014 cites W2001692359 @default.
• W2023582014 cites W2002468039 @default.
• W2023582014 cites W2009856702 @default.
• W2023582014 cites W2018052567 @default.
• W2023582014 cites W2021433243 @default.
• W2023582014 cites W2023184829 @default.
• W2023582014 cites W2036007824 @default.
• W2023582014 cites W2045948249 @default.
• W2023582014 cites W2047439478 @default.
• W2023582014 cites W2052130504 @default.
• W2023582014 cites W2053768301 @default.
• W2023582014 cites W2054800842 @default.
• W2023582014 cites W2064265012 @default.
• W2023582014 cites W2069834296 @default.
• W2023582014 cites W2073159198 @default.
• W2023582014 cites W2082954309 @default.
• W2023582014 cites W2126937206 @default.
• W2023582014 cites W2153799259 @default.
• W2023582014 cites W2171985697 @default.
• W2023582014 doi "https://doi.org/10.1111/j.1398-9995.1989.tb00439.x" @default.
• W2023582014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2470269" @default.
• W2023582014 hasPublicationYear "1989" @default.
• W2023582014 type Work @default.
• W2023582014 sameAs 2023582014 @default.
• W2023582014 citedByCount "4" @default.
• W2023582014 crossrefType "journal-article" @default.
• W2023582014 hasAuthorship W2023582014A5008633069 @default.
• W2023582014 hasAuthorship W2023582014A5029109482 @default.
• W2023582014 hasAuthorship W2023582014A5052054829 @default.
• W2023582014 hasConcept C1122143 @default.
• W2023582014 hasConcept C126322002 @default.
• W2023582014 hasConcept C134018914 @default.
• W2023582014 hasConcept C170493617 @default.
• W2023582014 hasConcept C184235292 @default.
• W2023582014 hasConcept C185592680 @default.
• W2023582014 hasConcept C195794163 @default.
• W2023582014 hasConcept C202751555 @default.
• W2023582014 hasConcept C2776711897 @default.
• W2023582014 hasConcept C2778001312 @default.
• W2023582014 hasConcept C2779281246 @default.
• W2023582014 hasConcept C2780043322 @default.
• W2023582014 hasConcept C2780161494 @default.
• W2023582014 hasConcept C55493867 @default.
• W2023582014 hasConcept C71924100 @default.
• W2023582014 hasConcept C98274493 @default.
• W2023582014 hasConceptScore W2023582014C1122143 @default.
• W2023582014 hasConceptScore W2023582014C126322002 @default.
• W2023582014 hasConceptScore W2023582014C134018914 @default.
• W2023582014 hasConceptScore W2023582014C170493617 @default.
• W2023582014 hasConceptScore W2023582014C184235292 @default.
• W2023582014 hasConceptScore W2023582014C185592680 @default.
• W2023582014 hasConceptScore W2023582014C195794163 @default.
• W2023582014 hasConceptScore W2023582014C202751555 @default.
• W2023582014 hasConceptScore W2023582014C2776711897 @default.
• W2023582014 hasConceptScore W2023582014C2778001312 @default.
• W2023582014 hasConceptScore W2023582014C2779281246 @default.
• W2023582014 hasConceptScore W2023582014C2780043322 @default.
• W2023582014 hasConceptScore W2023582014C2780161494 @default.
• W2023582014 hasConceptScore W2023582014C55493867 @default.
• W2023582014 hasConceptScore W2023582014C71924100 @default.
• W2023582014 hasConceptScore W2023582014C98274493 @default.
• W2023582014 hasLocation W20235820141 @default.
• W2023582014 hasLocation W20235820142 @default.
• W2023582014 hasOpenAccess W2023582014 @default.
• W2023582014 hasPrimaryLocation W20235820141 @default.
• W2023582014 hasRelatedWork W1516633954 @default.
• W2023582014 hasRelatedWork W1941714005 @default.
• W2023582014 hasRelatedWork W1996280073 @default.
• W2023582014 hasRelatedWork W2018630996 @default.
• W2023582014 hasRelatedWork W2022067822 @default.
• W2023582014 hasRelatedWork W2023582014 @default.
• W2023582014 hasRelatedWork W2031766799 @default.
• W2023582014 hasRelatedWork W2031945967 @default.
• W2023582014 hasRelatedWork W2047375461 @default.
• W2023582014 hasRelatedWork W2337194989 @default.
• W2023582014 isParatext "false" @default.
• W2023582014 isRetracted "false" @default.
• W2023582014 magId "2023582014" @default.
• W2023582014 workType "article" @default.