Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023582603> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2023582603 abstract "Abstract The enhancement in the transdermal delivery of arginine-vasopressin (AVP), a nonapeptide antidiuretic hormone (ADH), was studied using the Transdermal Periodic lontotherapeutic System (TPIS). The TPIS is capable of generating a pulse current at a specific combination of waveform, frequency and ON/OFF ratio. The in vitro permeation studies of AVP across the hairless rat skin was conducted under TPIS application and the results were compared with that by passive diffusion. Vasopressin was found to be relatively stable during the course of the experiment. The effect of pH and ionic strength of the donor solution and drug concentration on the AVP flux was evaluated. Under the application of TPIS, the transdermal delivery rate of AVP could be enhanced as much as 1000-fold and the degree of enhancement was noted to be dependent upon the physicochemical conditions used during the iontophoresis treatment. The flux of AVP at pH 5.0 and 7.4 was similar at constant ionic strength, but increased substantially as the ionic strength decreased. A linear relationship was established between AVP flux and AVP concentration in the donor compartment. The skin permeability enhanced by TPIS treatment is reversible and upon termination of iontophoretic application, the AVP flux was observed to return to that by passive diffusion alone." @default.
- W2023582603 created "2016-06-24" @default.
- W2023582603 creator A5001721857 @default.
- W2023582603 creator A5003833043 @default.
- W2023582603 creator A5018992422 @default.
- W2023582603 creator A5053104055 @default.
- W2023582603 date "1989-11-01" @default.
- W2023582603 modified "2023-09-27" @default.
- W2023582603 title "Transdermal iontophoretic delivery of arginine-vasopressin (I): Physicochemical considerations" @default.
- W2023582603 cites W186237373 @default.
- W2023582603 cites W1969117117 @default.
- W2023582603 cites W1986231025 @default.
- W2023582603 cites W2020519303 @default.
- W2023582603 cites W2036815885 @default.
- W2023582603 cites W2052866573 @default.
- W2023582603 cites W2060916590 @default.
- W2023582603 cites W2072330234 @default.
- W2023582603 cites W2077739831 @default.
- W2023582603 cites W2078796617 @default.
- W2023582603 cites W2110653835 @default.
- W2023582603 cites W2158622005 @default.
- W2023582603 doi "https://doi.org/10.1016/0378-5173(89)90055-0" @default.
- W2023582603 hasPublicationYear "1989" @default.
- W2023582603 type Work @default.
- W2023582603 sameAs 2023582603 @default.
- W2023582603 citedByCount "43" @default.
- W2023582603 countsByYear W20235826032015 @default.
- W2023582603 countsByYear W20235826032018 @default.
- W2023582603 countsByYear W20235826032021 @default.
- W2023582603 crossrefType "journal-article" @default.
- W2023582603 hasAuthorship W2023582603A5001721857 @default.
- W2023582603 hasAuthorship W2023582603A5003833043 @default.
- W2023582603 hasAuthorship W2023582603A5018992422 @default.
- W2023582603 hasAuthorship W2023582603A5053104055 @default.
- W2023582603 hasConcept C12554922 @default.
- W2023582603 hasConcept C126322002 @default.
- W2023582603 hasConcept C126838900 @default.
- W2023582603 hasConcept C134018914 @default.
- W2023582603 hasConcept C183529106 @default.
- W2023582603 hasConcept C185592680 @default.
- W2023582603 hasConcept C205679159 @default.
- W2023582603 hasConcept C2776370428 @default.
- W2023582603 hasConcept C2777468819 @default.
- W2023582603 hasConcept C2779420931 @default.
- W2023582603 hasConcept C43617362 @default.
- W2023582603 hasConcept C515207424 @default.
- W2023582603 hasConcept C55493867 @default.
- W2023582603 hasConcept C71924100 @default.
- W2023582603 hasConcept C86803240 @default.
- W2023582603 hasConcept C98274493 @default.
- W2023582603 hasConceptScore W2023582603C12554922 @default.
- W2023582603 hasConceptScore W2023582603C126322002 @default.
- W2023582603 hasConceptScore W2023582603C126838900 @default.
- W2023582603 hasConceptScore W2023582603C134018914 @default.
- W2023582603 hasConceptScore W2023582603C183529106 @default.
- W2023582603 hasConceptScore W2023582603C185592680 @default.
- W2023582603 hasConceptScore W2023582603C205679159 @default.
- W2023582603 hasConceptScore W2023582603C2776370428 @default.
- W2023582603 hasConceptScore W2023582603C2777468819 @default.
- W2023582603 hasConceptScore W2023582603C2779420931 @default.
- W2023582603 hasConceptScore W2023582603C43617362 @default.
- W2023582603 hasConceptScore W2023582603C515207424 @default.
- W2023582603 hasConceptScore W2023582603C55493867 @default.
- W2023582603 hasConceptScore W2023582603C71924100 @default.
- W2023582603 hasConceptScore W2023582603C86803240 @default.
- W2023582603 hasConceptScore W2023582603C98274493 @default.
- W2023582603 hasLocation W20235826031 @default.
- W2023582603 hasOpenAccess W2023582603 @default.
- W2023582603 hasPrimaryLocation W20235826031 @default.
- W2023582603 hasRelatedWork W128881153 @default.
- W2023582603 hasRelatedWork W130806548 @default.
- W2023582603 hasRelatedWork W1502413133 @default.
- W2023582603 hasRelatedWork W186237373 @default.
- W2023582603 hasRelatedWork W1969117117 @default.
- W2023582603 hasRelatedWork W1969936385 @default.
- W2023582603 hasRelatedWork W1975044572 @default.
- W2023582603 hasRelatedWork W2020519303 @default.
- W2023582603 hasRelatedWork W2026189427 @default.
- W2023582603 hasRelatedWork W2034208568 @default.
- W2023582603 hasRelatedWork W2079852052 @default.
- W2023582603 hasRelatedWork W2083814137 @default.
- W2023582603 hasRelatedWork W2086713061 @default.
- W2023582603 hasRelatedWork W2092737323 @default.
- W2023582603 hasRelatedWork W2110653835 @default.
- W2023582603 hasRelatedWork W2115092572 @default.
- W2023582603 hasRelatedWork W2158622005 @default.
- W2023582603 hasRelatedWork W2165812283 @default.
- W2023582603 hasRelatedWork W2167896369 @default.
- W2023582603 hasRelatedWork W327057840 @default.
- W2023582603 isParatext "false" @default.
- W2023582603 isRetracted "false" @default.
- W2023582603 magId "2023582603" @default.
- W2023582603 workType "article" @default.