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• W2023583278 startingPage "805" @default.
• W2023583278 abstract "The signaling mechanisms that control the survival of CNS neurons are poorly understood. Here we show that, in contrast to PNS neurons, the survival of purified postnatal rat retinal ganglion cells (RGCs) in vitro is not promoted by peptide trophic factors unless their intracellular cAMP is increased pharmacologically or they are depolarized by K+ or glutamate agonists. Long-term survival of most RGCs in culture can be promoted by a combination of trophic factors normally produced along the visual pathway, including BDNF, CNTF, IGF1, an oligodendrocyte-derived protein, and forskolin. These results suggest that neurotransmitter stimulation and electrical activity enhance the survival of developing RGCs and raise the question of whether the survival control mechanisms of PNS and CNS neurons are different." @default.
• W2023583278 created "2016-06-24" @default.
• W2023583278 creator A5027970945 @default.
• W2023583278 creator A5046557576 @default.
• W2023583278 creator A5052144876 @default.
• W2023583278 creator A5085786429 @default.
• W2023583278 date "1995-10-01" @default.
• W2023583278 modified "2023-10-14" @default.
• W2023583278 title "Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture" @default.
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