FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023583487> ?p ?o ?g. }

• W2023583487 endingPage "690" @default.
• W2023583487 startingPage "680" @default.
• W2023583487 abstract "Genome-wide association studies have identified a series of susceptibility loci for coronary artery disease(CAD). The present study attempted to replicate the results for eight of these loci, CDKN2A/B(rs1333049), ADTRP(rs6903956), PDGFD(rs974819), TCF21(rs12190287), COL4A1-A2(rs4773144), HHIPL1(rs2895811), ADAMTS7(rs4380028) and UBE2Z(rs46522), in patients with pathologically defined atherosclerosis of the coronary arteries.Autopsy cases of elderly Japanese subjects were enrolled in the JG-SNP study(n=1,536). Polymorphisms were genotyped, and their associations with the coronary stenosis index(CSI) and incidence of pathological myocardial infraction(MI) were investigated. The potential combinatorial effects of the susceptibility loci were also assessed.Among the eight loci tested, three exhibited signs of positive associations. CDKN2A/B showed the most robust associations with CSI and MI(p=0.007 and OR=1.843, 95% CI 1.293-2.629, p=0.001, for CC＋CG vs. GG). In addition, ADTRP demonstrated associations with CSI and MI, although the risk allele was opposite from that observed in the original report(p=0.008 and OR=1.652, 95% CI 1.027-2.656, p=0.038 for GG vs. AA＋AG). Meanwhile, PDGFD displayed a suggestive association with CSI in women, but not men(p=0.023). CDKN2A/B and ADTRP were also found to be significantly associated with the severity of the CSI in a case-control setting. The cumulative risk allele counting of CDKN2A/B, ADTRP and PDGFD indicated an increased number of risk alleles to be associated with a higher CSI(p=4.61E-05).The present study confirmed the association between CDKN2A/B and CAD and identified a different associated risk allele of ADTRP. PDGFD was found to exhibit a gender-specific association with CAD. The combination of multiple risk alleles may be associated with a higher risk of CAD." @default.
• W2023583487 created "2016-06-24" @default.
• W2023583487 creator A5004173815 @default.
• W2023583487 creator A5009286369 @default.
• W2023583487 creator A5021801449 @default.
• W2023583487 creator A5035249041 @default.
• W2023583487 creator A5043840057 @default.
• W2023583487 creator A5087785825 @default.
• W2023583487 date "2014-01-01" @default.
• W2023583487 modified "2023-10-16" @default.
• W2023583487 title "Associations between the CDKN2A/B, ADTRP and PDGFD Polymorphisms and the Development of Coronary Atherosclerosis in Japanese Patients" @default.
• W2023583487 cites W1964671303 @default.
• W2023583487 cites W1965265175 @default.
• W2023583487 cites W1978546929 @default.
• W2023583487 cites W1988691569 @default.
• W2023583487 cites W1999867237 @default.
• W2023583487 cites W2001401424 @default.
• W2023583487 cites W2018715352 @default.
• W2023583487 cites W2020229308 @default.
• W2023583487 cites W2026517602 @default.
• W2023583487 cites W2052269433 @default.
• W2023583487 cites W2071628128 @default.
• W2023583487 cites W2074705989 @default.
• W2023583487 cites W2076760973 @default.
• W2023583487 cites W2095821741 @default.
• W2023583487 cites W2099812691 @default.
• W2023583487 cites W2112848098 @default.
• W2023583487 cites W2120451046 @default.
• W2023583487 cites W2132038259 @default.
• W2023583487 cites W2134783591 @default.
• W2023583487 cites W2138358802 @default.
• W2023583487 cites W2141501509 @default.
• W2023583487 cites W2144062486 @default.
• W2023583487 cites W2168832434 @default.
• W2023583487 doi "https://doi.org/10.5551/jat.22640" @default.
• W2023583487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24573017" @default.
• W2023583487 hasPublicationYear "2014" @default.
• W2023583487 type Work @default.
• W2023583487 sameAs 2023583487 @default.
• W2023583487 citedByCount "35" @default.
• W2023583487 countsByYear W20235834872014 @default.
• W2023583487 countsByYear W20235834872015 @default.
• W2023583487 countsByYear W20235834872016 @default.
• W2023583487 countsByYear W20235834872017 @default.
• W2023583487 countsByYear W20235834872018 @default.
• W2023583487 countsByYear W20235834872019 @default.
• W2023583487 countsByYear W20235834872020 @default.
• W2023583487 countsByYear W20235834872021 @default.
• W2023583487 countsByYear W20235834872022 @default.
• W2023583487 countsByYear W20235834872023 @default.
• W2023583487 crossrefType "journal-article" @default.
• W2023583487 hasAuthorship W2023583487A5004173815 @default.
• W2023583487 hasAuthorship W2023583487A5009286369 @default.
• W2023583487 hasAuthorship W2023583487A5021801449 @default.
• W2023583487 hasAuthorship W2023583487A5035249041 @default.
• W2023583487 hasAuthorship W2023583487A5043840057 @default.
• W2023583487 hasAuthorship W2023583487A5087785825 @default.
• W2023583487 hasBestOaLocation W20235834871 @default.
• W2023583487 hasConcept C104317684 @default.
• W2023583487 hasConcept C120665830 @default.
• W2023583487 hasConcept C121332964 @default.
• W2023583487 hasConcept C121608353 @default.
• W2023583487 hasConcept C126322002 @default.
• W2023583487 hasConcept C135763542 @default.
• W2023583487 hasConcept C139275648 @default.
• W2023583487 hasConcept C153209595 @default.
• W2023583487 hasConcept C164705383 @default.
• W2023583487 hasConcept C180754005 @default.
• W2023583487 hasConcept C2776820930 @default.
• W2023583487 hasConcept C2778213512 @default.
• W2023583487 hasConcept C2778742706 @default.
• W2023583487 hasConcept C2780265364 @default.
• W2023583487 hasConcept C54355233 @default.
• W2023583487 hasConcept C61511704 @default.
• W2023583487 hasConcept C71924100 @default.
• W2023583487 hasConcept C86803240 @default.
• W2023583487 hasConcept C90924648 @default.
• W2023583487 hasConceptScore W2023583487C104317684 @default.
• W2023583487 hasConceptScore W2023583487C120665830 @default.
• W2023583487 hasConceptScore W2023583487C121332964 @default.
• W2023583487 hasConceptScore W2023583487C121608353 @default.
• W2023583487 hasConceptScore W2023583487C126322002 @default.
• W2023583487 hasConceptScore W2023583487C135763542 @default.
• W2023583487 hasConceptScore W2023583487C139275648 @default.
• W2023583487 hasConceptScore W2023583487C153209595 @default.
• W2023583487 hasConceptScore W2023583487C164705383 @default.
• W2023583487 hasConceptScore W2023583487C180754005 @default.
• W2023583487 hasConceptScore W2023583487C2776820930 @default.
• W2023583487 hasConceptScore W2023583487C2778213512 @default.
• W2023583487 hasConceptScore W2023583487C2778742706 @default.
• W2023583487 hasConceptScore W2023583487C2780265364 @default.
• W2023583487 hasConceptScore W2023583487C54355233 @default.
• W2023583487 hasConceptScore W2023583487C61511704 @default.
• W2023583487 hasConceptScore W2023583487C71924100 @default.
• W2023583487 hasConceptScore W2023583487C86803240 @default.
• W2023583487 hasConceptScore W2023583487C90924648 @default.
• W2023583487 hasIssue "7" @default.
• W2023583487 hasLocation W20235834871 @default.

• next