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• W2023583823 endingPage "466" @default.
• W2023583823 startingPage "457" @default.
• W2023583823 abstract "Although chromosome mis-segregation is a hallmark of cancer cells, its genetic basis and role in malignant transformation remain poorly understood. In recent years, several mouse models have been generated that harbor gene defects that perturb high-fidelity chromosome segregation. Analysis of these models has revealed that whole chromosome instability (W-CIN) can cause, inhibit or have no effect on tumorigenesis. Here we propose that the effect of W-CIN on tumor development depends on the particular W-CIN gene that is defective, including its other cellular functions, the extent or nature of the gene defect, the affected tissue or cell type and the context of other cancer gene mutations." @default.
• W2023583823 created "2016-06-24" @default.
• W2023583823 creator A5029077651 @default.
• W2023583823 creator A5044143444 @default.
• W2023583823 creator A5049394710 @default.
• W2023583823 date "2008-09-01" @default.
• W2023583823 modified "2023-10-05" @default.
• W2023583823 title "Whole chromosome instability and cancer: a complex relationship" @default.
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• W2023583823 doi "https://doi.org/10.1016/j.tig.2008.07.002" @default.
• W2023583823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2594012" @default.
• W2023583823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18675487" @default.
• W2023583823 hasPublicationYear "2008" @default.
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