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• W2023584631 abstract "In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures. Thus, a process dependent on the NMDA receptor-ionophore complex establishes a long-lasting, seizure-prone state; thereafter the seizures depend on non-NMDA receptor-ionophore mechanisms. This suggests that there is an important distinction between epileptogenesis and seizure expression and between antiepileptogenic and anticonvulsant pharmacological agents." @default.
• W2023584631 created "2016-06-24" @default.
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• W2023584631 date "1989-08-11" @default.
• W2023584631 modified "2023-10-11" @default.
• W2023584631 title "NMDA Antagonists Differentiate Epileptogenesis from Seizure Expression in an in Vitro Model" @default.
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• W2023584631 doi "https://doi.org/10.1126/science.2569762" @default.
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