FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023584645> ?p ?o ?g. }

• W2023584645 endingPage "1042" @default.
• W2023584645 startingPage "1030" @default.
• W2023584645 abstract "rel/nf-kappaB genes are amplified, overexpressed, or constitutively activated in many human hematopoietic tumors; however, the molecular mechanisms by which they contribute to tumorigenesis remain to be determined. Here, we explored the oncogenic potential of cellular Rel/NF-kappaB proteins in vitro and in vivo. We show that overexpression of wild-type mouse and human c-rel genes suffices to malignantly transform primary spleen cells in stringent soft agar assays and produce fatal tumors in vivo. In contrast relA and a constitutively active form of IKKbeta did not. Importantly, a hybrid RelA protein with its C-terminal transactivation domain substituted by that of v-Rel was potently oncogenic in vitro and in vivo. The transactivation domain of v-Rel selectively conferred an oncogenic phenotype upon the Rel homology domain (RHD) of RelA, but not to the more divergent RHDs of p50/NF-kappaB1, p52/NF-kappaB2, or RelB. Collectively, our results highlight important differences in the intrinsic oncogenic activity of mammalian c-Rel and RelA proteins, and indicate that critical determinants of their differential oncogenicity reside in their divergent transactivation domains. These findings provide experimental evidence for a role of mammalian Rel/NF-kappaB factors in leukemia/lymphomagenesis in an in vivo animal model, and are consistent with the implication of c-rel in many human lymphomas." @default.
• W2023584645 created "2016-06-24" @default.
• W2023584645 creator A5028603969 @default.
• W2023584645 creator A5040647062 @default.
• W2023584645 creator A5051688844 @default.
• W2023584645 date "2003-12-01" @default.
• W2023584645 modified "2023-10-18" @default.
• W2023584645 title "Divergent C-terminal transactivation domains of Rel/NF-κB proteins are critical determinants of their oncogenic potential in lymphocytes" @default.
• W2023584645 cites W1518023495 @default.
• W2023584645 cites W1535776410 @default.
• W2023584645 cites W1580723864 @default.
• W2023584645 cites W1586722842 @default.
• W2023584645 cites W1653579635 @default.
• W2023584645 cites W1814410326 @default.
• W2023584645 cites W1838161630 @default.
• W2023584645 cites W1878556561 @default.
• W2023584645 cites W1891648127 @default.
• W2023584645 cites W1897976104 @default.
• W2023584645 cites W1954929088 @default.
• W2023584645 cites W1964277592 @default.
• W2023584645 cites W1968178844 @default.
• W2023584645 cites W1975084250 @default.
• W2023584645 cites W1983771472 @default.
• W2023584645 cites W1987099700 @default.
• W2023584645 cites W1990895107 @default.
• W2023584645 cites W1992617765 @default.
• W2023584645 cites W1994915896 @default.
• W2023584645 cites W1998574404 @default.
• W2023584645 cites W1999141617 @default.
• W2023584645 cites W2002630364 @default.
• W2023584645 cites W2007456673 @default.
• W2023584645 cites W2008569721 @default.
• W2023584645 cites W2008632158 @default.
• W2023584645 cites W2016730049 @default.
• W2023584645 cites W2027260180 @default.
• W2023584645 cites W2029381336 @default.
• W2023584645 cites W2031208947 @default.
• W2023584645 cites W2032531389 @default.
• W2023584645 cites W2033624366 @default.
• W2023584645 cites W2051994734 @default.
• W2023584645 cites W2064201629 @default.
• W2023584645 cites W2064208261 @default.
• W2023584645 cites W2070702404 @default.
• W2023584645 cites W2075172606 @default.
• W2023584645 cites W2079335591 @default.
• W2023584645 cites W2086941505 @default.
• W2023584645 cites W2093877091 @default.
• W2023584645 cites W2096784993 @default.
• W2023584645 cites W2101259699 @default.
• W2023584645 cites W2103339981 @default.
• W2023584645 cites W2104697096 @default.
• W2023584645 cites W2106038332 @default.
• W2023584645 cites W2108576833 @default.
• W2023584645 cites W2110440735 @default.
• W2023584645 cites W2113790334 @default.
• W2023584645 cites W2116397785 @default.
• W2023584645 cites W2116482468 @default.
• W2023584645 cites W2122275228 @default.
• W2023584645 cites W2126214983 @default.
• W2023584645 cites W2136426653 @default.
• W2023584645 cites W2138606537 @default.
• W2023584645 cites W2140288732 @default.
• W2023584645 cites W2143263914 @default.
• W2023584645 cites W2147246240 @default.
• W2023584645 cites W2147921405 @default.
• W2023584645 cites W2157676659 @default.
• W2023584645 cites W2164091330 @default.
• W2023584645 cites W2171865516 @default.
• W2023584645 cites W2318334567 @default.
• W2023584645 cites W2321485234 @default.
• W2023584645 cites W2325651372 @default.
• W2023584645 cites W2332387324 @default.
• W2023584645 cites W2332897912 @default.
• W2023584645 cites W2334425364 @default.
• W2023584645 cites W2999065750 @default.
• W2023584645 cites W306915739 @default.
• W2023584645 cites W4230961371 @default.
• W2023584645 cites W4233779450 @default.
• W2023584645 cites W4234189176 @default.
• W2023584645 cites W4235217704 @default.
• W2023584645 cites W4247158775 @default.
• W2023584645 cites W4293247451 @default.
• W2023584645 cites W4379365691 @default.
• W2023584645 cites W51542665 @default.
• W2023584645 cites W2469267771 @default.
• W2023584645 doi "https://doi.org/10.1038/sj.onc.1207221" @default.
• W2023584645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14647412" @default.
• W2023584645 hasPublicationYear "2003" @default.
• W2023584645 type Work @default.
• W2023584645 sameAs 2023584645 @default.
• W2023584645 citedByCount "28" @default.
• W2023584645 countsByYear W20235846452012 @default.
• W2023584645 countsByYear W20235846452013 @default.
• W2023584645 countsByYear W20235846452015 @default.
• W2023584645 countsByYear W20235846452017 @default.
• W2023584645 countsByYear W20235846452019 @default.
• W2023584645 crossrefType "journal-article" @default.
• W2023584645 hasAuthorship W2023584645A5028603969 @default.

• next