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• W2023587164 endingPage "1318" @default.
• W2023587164 startingPage "1314" @default.
• W2023587164 abstract "Interferon inhibits expression of human immunodeficiency virus type-1 (HIV-1) through unknown mechanisms. A gene inducible by interferon-alpha (IFN-alpha) and interferon-gamma (IFN-gamma) was isolated by screening of a human complementary DNA library for proteins binding to the Rev-responsive element (RRE) of HIV-1. The product of this gene, RBP9-27, was shown to bind RNA in vitro and to inhibit HIV-1 expression after transfection into human cells. RBP9-27 primarily inhibited Rev-dependent posttranscriptional steps of viral gene expression. Thus, RBP9-27 is a cellular factor that antagonizes Rev function. These results suggest an interferon-induced antiviral mechanism operating through the induction of RNA binding proteins such as RBP9-27. Elucidation of RBP9-27 function may lead to a better understanding of the mechanism of interferon action during HIV-1 infection." @default.
• W2023587164 created "2016-06-24" @default.
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• W2023587164 date "1993-02-26" @default.
• W2023587164 modified "2023-10-18" @default.
• W2023587164 title "Inhibition of Rev-Mediated HIV-1 Expression by an RNA Binding Protein Encoded by the Interferon-Inducible 9-27 Gene" @default.
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• W2023587164 doi "https://doi.org/10.1126/science.7680491" @default.
• W2023587164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7680491" @default.
• W2023587164 hasPublicationYear "1993" @default.
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