FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023587691> ?p ?o ?g. }

• W2023587691 endingPage "234" @default.
• W2023587691 startingPage "225" @default.
• W2023587691 abstract "Due to their beneficial effect on selectivity, peak shape, and sample loading, the use of mobile phase anionic additives, such as formate (HCOO−), chloride (Cl−), and trifluoroacetate (CF3COO−), is increasing in both reversed-phase chromatography (RPLC) and liquid chromatography-mass spectrometry (LC/MS). Similarly, perchlorate is a common “ion pair” agent in reversed-phase separation of peptides. Although many studies have suggested that anions effect in chromatography is due to the formation of ion pairs in the mobile phase between the anions and cationic analytes, there has been no independent verification that ion pairs are, in fact, responsible for these observations. In order to understand the mechanisms by which anionic additives influence retention in chromatography and ionization efficiency in electrospray mass spectrometry, we studied the formation of ion pairs between a number of prototypical basic drugs and various additives by measuring the effect of anionic additives on the electrophoretic mobility of the probe drugs under solvent conditions commonly used in chromatography. For the first time, ion pair formation between basic drugs and anionic additives under conditions commonly used in reversed-phase liquid chromatography has been confirmed independently with all anions (i.e. hexafluorophosphate, perchlorate, trifluoroacetate, and chloride) used in this study. We measured ion pair formation constants (Kip) for different anionic additives using capillary electrophoresis (CE) and obtained quantitative estimates for the extent of ion pairing in buffered acetonitrile–water. The data clearly indicate that different anionic additives ion pair with cationic drugs to quite different extents. The ion pair formation constants show a clear trend with the order being: PF6− > ClO4− > CF3COO− > Cl−. However, the extent of ion pairing is not large. At a typical RPLC mobile phase additive concentration of 20 mM, the percentages of the analytes that are present as ion pairs are about 15%, 6%, and 3% for hexafluorophosphate, perchlorate, and trifluoroacetate, respectively. The fraction of the analytes present as a chloride pair is even smaller." @default.
• W2023587691 created "2016-06-24" @default.
• W2023587691 creator A5009966491 @default.
• W2023587691 creator A5019899850 @default.
• W2023587691 creator A5021678168 @default.
• W2023587691 creator A5026900423 @default.
• W2023587691 creator A5082263870 @default.
• W2023587691 date "2005-04-01" @default.
• W2023587691 modified "2023-10-17" @default.
• W2023587691 title "Effect of anionic additive type on ion pair formation constants of basic pharmaceuticals" @default.
• W2023587691 cites W114134963 @default.
• W2023587691 cites W162472049 @default.
• W2023587691 cites W171604263 @default.
• W2023587691 cites W18455514 @default.
• W2023587691 cites W1973038361 @default.
• W2023587691 cites W1973750175 @default.
• W2023587691 cites W1974186522 @default.
• W2023587691 cites W1974206425 @default.
• W2023587691 cites W1974658886 @default.
• W2023587691 cites W1975727760 @default.
• W2023587691 cites W1976267380 @default.
• W2023587691 cites W1979930369 @default.
• W2023587691 cites W1986350555 @default.
• W2023587691 cites W1996383810 @default.
• W2023587691 cites W1999701124 @default.
• W2023587691 cites W2002136892 @default.
• W2023587691 cites W2010838462 @default.
• W2023587691 cites W2011266811 @default.
• W2023587691 cites W2013426122 @default.
• W2023587691 cites W2017429828 @default.
• W2023587691 cites W2017720737 @default.
• W2023587691 cites W2019257695 @default.
• W2023587691 cites W2020367737 @default.
• W2023587691 cites W2020977833 @default.
• W2023587691 cites W2028962912 @default.
• W2023587691 cites W2030446995 @default.
• W2023587691 cites W2034532845 @default.
• W2023587691 cites W2034562096 @default.
• W2023587691 cites W2036239180 @default.
• W2023587691 cites W2037321686 @default.
• W2023587691 cites W2037913704 @default.
• W2023587691 cites W2041605343 @default.
• W2023587691 cites W2043716701 @default.
• W2023587691 cites W2047408809 @default.
• W2023587691 cites W2057144898 @default.
• W2023587691 cites W2057358811 @default.
• W2023587691 cites W2067010736 @default.
• W2023587691 cites W2067346569 @default.
• W2023587691 cites W2075745577 @default.
• W2023587691 cites W2075770614 @default.
• W2023587691 cites W2077006735 @default.
• W2023587691 cites W2080406238 @default.
• W2023587691 cites W2084035299 @default.
• W2023587691 cites W2084183082 @default.
• W2023587691 cites W2089166639 @default.
• W2023587691 cites W2195216396 @default.
• W2023587691 cites W224351928 @default.
• W2023587691 cites W2495285817 @default.
• W2023587691 cites W4229989555 @default.
• W2023587691 doi "https://doi.org/10.1016/j.chroma.2005.02.030" @default.
• W2023587691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15830949" @default.
• W2023587691 hasPublicationYear "2005" @default.
• W2023587691 type Work @default.
• W2023587691 sameAs 2023587691 @default.
• W2023587691 citedByCount "54" @default.
• W2023587691 countsByYear W20235876912012 @default.
• W2023587691 countsByYear W20235876912013 @default.
• W2023587691 countsByYear W20235876912014 @default.
• W2023587691 countsByYear W20235876912017 @default.
• W2023587691 countsByYear W20235876912018 @default.
• W2023587691 countsByYear W20235876912019 @default.
• W2023587691 countsByYear W20235876912020 @default.
• W2023587691 crossrefType "journal-article" @default.
• W2023587691 hasAuthorship W2023587691A5009966491 @default.
• W2023587691 hasAuthorship W2023587691A5019899850 @default.
• W2023587691 hasAuthorship W2023587691A5021678168 @default.
• W2023587691 hasAuthorship W2023587691A5026900423 @default.
• W2023587691 hasAuthorship W2023587691A5082263870 @default.
• W2023587691 hasConcept C145148216 @default.
• W2023587691 hasConcept C162356407 @default.
• W2023587691 hasConcept C178790620 @default.
• W2023587691 hasConcept C179104552 @default.
• W2023587691 hasConcept C183882617 @default.
• W2023587691 hasConcept C185592680 @default.
• W2023587691 hasConcept C206967267 @default.
• W2023587691 hasConcept C2777463227 @default.
• W2023587691 hasConcept C2778695967 @default.
• W2023587691 hasConcept C2780471494 @default.
• W2023587691 hasConcept C2780709120 @default.
• W2023587691 hasConcept C40684141 @default.
• W2023587691 hasConcept C43617362 @default.
• W2023587691 hasConceptScore W2023587691C145148216 @default.
• W2023587691 hasConceptScore W2023587691C162356407 @default.
• W2023587691 hasConceptScore W2023587691C178790620 @default.
• W2023587691 hasConceptScore W2023587691C179104552 @default.
• W2023587691 hasConceptScore W2023587691C183882617 @default.
• W2023587691 hasConceptScore W2023587691C185592680 @default.
• W2023587691 hasConceptScore W2023587691C206967267 @default.

• next