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- W2023589404 abstract "Mechanisms of intestinal salicylamide glucuronide formation and transport were studied in the rabbit with in vitro, cannulated everted intestines and in vivo perfused and closed loops with complete mesenteric venous blood collection. Both experimental techniques indicate that glucuronide formation is capacity limited when the lumen concentration exceeds 10−3M. The glucuronide‐to‐free drug ratio appearing in mesenteric blood (in vivo) and serosal fluid (in vitro) decreases with increasing lumen concentrations. Appearance of glucuronide across the basal barrier is limited by the transport step rather than the rate of glucuronide synthesis leading to accumulation of glucuronide in the tissue compartment. Transport of glucuronide appears to be a simple first‐order diffusion process into the lumen contents as well as the mesenteric blood. Some implications of these findings in pharmacokinetic studies and dosage form design are discussed." @default.
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- W2023589404 title "Intestinal Drug Absorption and Metabolism II: Kinetic Aspects of Intestinal Glucuronide Conjugation" @default.
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- W2023589404 doi "https://doi.org/10.1002/jps.2600590205" @default.
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