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- W2023590105 abstract "Functional imaging of an animals thoracic region requires cardiac and respiratory gating. The information onrespiratory motion and ECG required for double-gating are extracted from the rawdata and used to select theprojections appropriate for a given motion phase. A conventional phase-correlated reconstruction (PC) thereforeuses only a small amount of the total projections acquired. Thus the resulting images comprise a high noiselevel unless acquired with very high dose, and streak artifacts may occur due to the sparse angular sampling.Here, we are aiming at getting high fidelity images even for relatively low dose values. To overcome these issueswe implemented an iterative reconstruction method encompassing a five-dimensional (spatial, cardiac-temporal,respiratory-temporal) edge-preserving filter. This new phase-correlated low-dose (LDPC) reconstruction methodis evaluated using retrospectively-gated, contrast-enhanced micro CT data of mice. The scans performed comprise7200 projections within 10 rotations over 5 minutes. A tube voltage of 65 kV was used resulting in anadministered dose of about 500 mGy. 20 respiratory phases and 10 cardiac phases are reconstructed. UsingLDPC reconstruction the image noise is typically reduced by a factor of about six and artifacts are almostremoved. Reducing the number of projections available for reconstruction shows that we can get comparableimage quality with only 200 mGy. LDPC enables high fidelity low-dose double-gated imaging of free breathingrodents without compromises in image quality. Compared to PC image noise is significantly reduced with LDPCand the administered dose can be reduced accordingly." @default.
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- W2023590105 date "2011-03-03" @default.
- W2023590105 modified "2023-09-23" @default.
- W2023590105 title "Functional phase-correlated micro-CT imaging of small rodents with low dose" @default.
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- W2023590105 doi "https://doi.org/10.1117/12.877343" @default.
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