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• W2023590131 abstract "Picornavirus Type 1 IRESs comprise five principal domains (dII-dVI). Whereas dV binds eIF4G, a conserved AUG in dVI was suggested to stimulate attachment of 43S ribosomal preinitiation complexes, which then scan to the initiation codon. Initiation on Type 1 IRESs also requires IRES trans-acting factors (ITAFs), and several candidates have been proposed. Here, we report the in vitro reconstitution of initiation on three Type 1 IRESs: poliovirus (PV), enterovirus 71 (EV71), and bovine enterovirus (BEV). All of them require eIF2, eIF3, eIF4A, eIF4G, eIF4B, eIF1A, and a single ITAF, poly(C) binding protein 2 (PCBP2). In each instance, initiation starts with binding of eIF4G/eIF4A. Subsequent recruitment of 43S complexes strictly requires direct interaction of their eIF3 constituent with eIF4G. The following events can differ between IRESs, depending on the stability of dVI. If it is unstructured (BEV), all ribosomes scan through dVI to the initiation codon, requiring eIF1 to bypass its AUG. If it is structured (PV, EV71), most initiation events occur without inspection of dVI, implying that its AUG does not determine ribosomal attachment." @default.
• W2023590131 created "2016-06-24" @default.
• W2023590131 creator A5009915941 @default.
• W2023590131 creator A5014301105 @default.
• W2023590131 creator A5067570812 @default.
• W2023590131 creator A5085513802 @default.
• W2023590131 date "2013-12-16" @default.
• W2023590131 modified "2023-09-30" @default.
• W2023590131 title "The mechanism of translation initiation on Type 1 picornavirus IRESs" @default.
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• W2023590131 doi "https://doi.org/10.1002/embj.201386124" @default.
• W2023590131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3990684" @default.
• W2023590131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24357634" @default.
• W2023590131 hasPublicationYear "2013" @default.
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