FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023590150> ?p ?o ?g. }

• W2023590150 endingPage "428" @default.
• W2023590150 startingPage "419" @default.
• W2023590150 abstract "Interleukin (IL)-17A plays an important role in the cerebral ischemia/reperfusion (I/R) injury. However, the mechanisms are still largely unknown. Calpain-transient receptor potential canonical (subtype) 6 (TRPC6) signaling pathway has been recently found to be implicated in brain I/R injury. However, their relationships with IL-17A remain unknown. This study aims to test whether this important signaling has correlation with IL-17A and how they led to the neuronal damage in I/R injury. In the present study, mice were subjected to middle cerebral artery occlusion (60 min) followed by reperfusion for different times. Infarct volumes and neurological deficits were examined. Real-time PCR (RT-PCR) and Western blotting were conducted to detect IL-17A expression in the penumbral brain tissue. Activation of calpain and expression of TRPC6 were also studied. We found that cerebral I/R significantly increased the levels of IL-17A at 1, 3 and 6 days after reperfusion in the penumbral area. IL-17A knockout or anti-IL-17A monoclonal antibody (mAb) significantly reduced whereas recombinant mouse-IL-17A (rIL-17A) increased the activation of calpain at 3 days after reperfusion. The calpain specific inhibitor calpeptin significantly increased TRPC6 expression. Brain injury and neurological deficits were largely abrogated by IL-17A knockout, anti-IL-17A mAb or calpeptin. Recombinant IL-17A treatment markedly increased I/R injury. In conclusion, IL-17A may promote brain I/R injury through the increase of calpain-mediated TRPC6 proteolysis. These results further outline a novel neuroprotective strategy with increased effectiveness for the inhibition of excess brain IL-17A in cerebral I/R injury." @default.
• W2023590150 created "2016-06-24" @default.
• W2023590150 creator A5000529473 @default.
• W2023590150 creator A5035672227 @default.
• W2023590150 creator A5036633220 @default.
• W2023590150 creator A5063307513 @default.
• W2023590150 creator A5081341048 @default.
• W2023590150 date "2014-08-01" @default.
• W2023590150 modified "2023-09-25" @default.
• W2023590150 title "IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice" @default.
• W2023590150 cites W1964187920 @default.
• W2023590150 cites W1985593374 @default.
• W2023590150 cites W2009611544 @default.
• W2023590150 cites W2013900800 @default.
• W2023590150 cites W2017046428 @default.
• W2023590150 cites W2017941203 @default.
• W2023590150 cites W2020279479 @default.
• W2023590150 cites W2023749167 @default.
• W2023590150 cites W2025369883 @default.
• W2023590150 cites W2027729490 @default.
• W2023590150 cites W2034861293 @default.
• W2023590150 cites W2058333671 @default.
• W2023590150 cites W2060527543 @default.
• W2023590150 cites W2062380793 @default.
• W2023590150 cites W2063576193 @default.
• W2023590150 cites W2071002641 @default.
• W2023590150 cites W2080695699 @default.
• W2023590150 cites W2084899362 @default.
• W2023590150 cites W2091180924 @default.
• W2023590150 cites W2097756768 @default.
• W2023590150 cites W2129078075 @default.
• W2023590150 cites W2132305654 @default.
• W2023590150 cites W2136784260 @default.
• W2023590150 cites W2140740165 @default.
• W2023590150 cites W2144884256 @default.
• W2023590150 cites W2144890529 @default.
• W2023590150 cites W2149023741 @default.
• W2023590150 cites W2149225235 @default.
• W2023590150 cites W2150842829 @default.
• W2023590150 cites W2159233098 @default.
• W2023590150 cites W2164996299 @default.
• W2023590150 cites W22231678 @default.
• W2023590150 cites W2792583460 @default.
• W2023590150 cites W4210973470 @default.
• W2023590150 doi "https://doi.org/10.1016/j.neuroscience.2014.06.001" @default.
• W2023590150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24928352" @default.
• W2023590150 hasPublicationYear "2014" @default.
• W2023590150 type Work @default.
• W2023590150 sameAs 2023590150 @default.
• W2023590150 citedByCount "68" @default.
• W2023590150 countsByYear W20235901502015 @default.
• W2023590150 countsByYear W20235901502016 @default.
• W2023590150 countsByYear W20235901502017 @default.
• W2023590150 countsByYear W20235901502018 @default.
• W2023590150 countsByYear W20235901502019 @default.
• W2023590150 countsByYear W20235901502020 @default.
• W2023590150 countsByYear W20235901502021 @default.
• W2023590150 countsByYear W20235901502022 @default.
• W2023590150 countsByYear W20235901502023 @default.
• W2023590150 crossrefType "journal-article" @default.
• W2023590150 hasAuthorship W2023590150A5000529473 @default.
• W2023590150 hasAuthorship W2023590150A5035672227 @default.
• W2023590150 hasAuthorship W2023590150A5036633220 @default.
• W2023590150 hasAuthorship W2023590150A5063307513 @default.
• W2023590150 hasAuthorship W2023590150A5081341048 @default.
• W2023590150 hasConcept C126322002 @default.
• W2023590150 hasConcept C128448793 @default.
• W2023590150 hasConcept C155164980 @default.
• W2023590150 hasConcept C170493617 @default.
• W2023590150 hasConcept C181199279 @default.
• W2023590150 hasConcept C182704531 @default.
• W2023590150 hasConcept C185592680 @default.
• W2023590150 hasConcept C25498285 @default.
• W2023590150 hasConcept C2776914184 @default.
• W2023590150 hasConcept C2780114680 @default.
• W2023590150 hasConcept C47348012 @default.
• W2023590150 hasConcept C541997718 @default.
• W2023590150 hasConcept C55493867 @default.
• W2023590150 hasConcept C56928146 @default.
• W2023590150 hasConcept C71924100 @default.
• W2023590150 hasConcept C86803240 @default.
• W2023590150 hasConcept C98274493 @default.
• W2023590150 hasConceptScore W2023590150C126322002 @default.
• W2023590150 hasConceptScore W2023590150C128448793 @default.
• W2023590150 hasConceptScore W2023590150C155164980 @default.
• W2023590150 hasConceptScore W2023590150C170493617 @default.
• W2023590150 hasConceptScore W2023590150C181199279 @default.
• W2023590150 hasConceptScore W2023590150C182704531 @default.
• W2023590150 hasConceptScore W2023590150C185592680 @default.
• W2023590150 hasConceptScore W2023590150C25498285 @default.
• W2023590150 hasConceptScore W2023590150C2776914184 @default.
• W2023590150 hasConceptScore W2023590150C2780114680 @default.
• W2023590150 hasConceptScore W2023590150C47348012 @default.
• W2023590150 hasConceptScore W2023590150C541997718 @default.
• W2023590150 hasConceptScore W2023590150C55493867 @default.
• W2023590150 hasConceptScore W2023590150C56928146 @default.
• W2023590150 hasConceptScore W2023590150C71924100 @default.
• W2023590150 hasConceptScore W2023590150C86803240 @default.

• next