FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023592001> ?p ?o ?g. }

• W2023592001 endingPage "768" @default.
• W2023592001 startingPage "761" @default.
• W2023592001 abstract "Our aim was to investigate the mechanisms involved in the high intracellular sodium-induced transmitter release in the CNS through the characterisation of the veratridine-evoked (40 microM) noradrenaline release from rat hippocampal slices. The response to veratridine was completely inhibited by tetrodotoxin (1 microM), indicating that the effect is due to the activation of sodium channels. Omission of Ca2+ from the superfusion fluid inhibited the veratridine-evoked release by 72%, showing that the majority of release results from external Ca2+-dependent exocytosis. The residual Ca2+-independent release was not blocked by the intracellular Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid acetoxymethyl ester (100 microM) suggesting that intracellular Ca2+ stores are not involved in this component of veratridine effect. The noradrenaline uptake blockers, desipramine (10 microM) and nisoxetine (10 microM), inhibited the external Ca2+-independent release by 50 and 46%, respectively, indicating that the release partly originates from the reversal of transporters (carrier-mediated release). In contrast to uptake blockers, lowering the temperature, another possibility to inhibit transporter function, completely inhibited the effect of veratridine in the absence of Ca2+. Further experiments revealed that low temperature (20 and 12 degrees C) reduces the veratridine-induced increase of intracellular sodium concentration ([Na+]i) in rat cortical synaptosomes (68 and 78% inhibition, respectively). The clinical relevance of our data is that during ischemia a massive release of transmitters occurs mainly due to the elevation of [Na+]i, which contributes to the development of ischemic brain injury. Our results show that low temperature may be a better therapeutic approach to the treatment of ischemia because it has a dual action on this process. Firstly, it inhibits the function of uptake transporters and hence reduces the carrier-mediated outflow of transmitters. Secondly, it inhibits the sodium influx and therefore prevents the unwanted elevation of [Na+]i. Our data also suggest that veratridine stimulation can be a suitable model for ischemic conditions." @default.
• W2023592001 created "2016-06-24" @default.
• W2023592001 creator A5010858573 @default.
• W2023592001 creator A5013083618 @default.
• W2023592001 creator A5040811208 @default.
• W2023592001 creator A5053144324 @default.
• W2023592001 creator A5054084457 @default.
• W2023592001 creator A5060528721 @default.
• W2023592001 creator A5085768446 @default.
• W2023592001 date "2001-06-01" @default.
• W2023592001 modified "2023-10-17" @default.
• W2023592001 title "Analysis of high intracellular [Na+]-induced release of [3H]noradrenaline in rat hippocampal slices" @default.
• W2023592001 cites W1654539323 @default.
• W2023592001 cites W1788957748 @default.
• W2023592001 cites W1972653771 @default.
• W2023592001 cites W1975322631 @default.
• W2023592001 cites W1978737181 @default.
• W2023592001 cites W1988548531 @default.
• W2023592001 cites W1990616763 @default.
• W2023592001 cites W1990673766 @default.
• W2023592001 cites W1990955856 @default.
• W2023592001 cites W1994814395 @default.
• W2023592001 cites W1998872124 @default.
• W2023592001 cites W2019099519 @default.
• W2023592001 cites W2020420593 @default.
• W2023592001 cites W2023707009 @default.
• W2023592001 cites W2032480090 @default.
• W2023592001 cites W2032492737 @default.
• W2023592001 cites W2036005081 @default.
• W2023592001 cites W2042841623 @default.
• W2023592001 cites W2053139861 @default.
• W2023592001 cites W2057053236 @default.
• W2023592001 cites W2057891326 @default.
• W2023592001 cites W2060889205 @default.
• W2023592001 cites W2063100823 @default.
• W2023592001 cites W2067856604 @default.
• W2023592001 cites W2072009296 @default.
• W2023592001 cites W2073167421 @default.
• W2023592001 cites W2076521884 @default.
• W2023592001 cites W2079610613 @default.
• W2023592001 cites W2082120295 @default.
• W2023592001 cites W2083366258 @default.
• W2023592001 cites W2087673676 @default.
• W2023592001 cites W2095136980 @default.
• W2023592001 cites W2095617629 @default.
• W2023592001 cites W2098862658 @default.
• W2023592001 cites W2111897603 @default.
• W2023592001 cites W2116884014 @default.
• W2023592001 cites W2140527786 @default.
• W2023592001 cites W2143937294 @default.
• W2023592001 cites W2226936827 @default.
• W2023592001 cites W2092541089 @default.
• W2023592001 doi "https://doi.org/10.1016/s0306-4522(01)00102-6" @default.
• W2023592001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11440807" @default.
• W2023592001 hasPublicationYear "2001" @default.
• W2023592001 type Work @default.
• W2023592001 sameAs 2023592001 @default.
• W2023592001 citedByCount "27" @default.
• W2023592001 countsByYear W20235920012013 @default.
• W2023592001 countsByYear W20235920012014 @default.
• W2023592001 countsByYear W20235920012015 @default.
• W2023592001 countsByYear W20235920012017 @default.
• W2023592001 countsByYear W20235920012019 @default.
• W2023592001 countsByYear W20235920012020 @default.
• W2023592001 countsByYear W20235920012022 @default.
• W2023592001 crossrefType "journal-article" @default.
• W2023592001 hasAuthorship W2023592001A5010858573 @default.
• W2023592001 hasAuthorship W2023592001A5013083618 @default.
• W2023592001 hasAuthorship W2023592001A5040811208 @default.
• W2023592001 hasAuthorship W2023592001A5053144324 @default.
• W2023592001 hasAuthorship W2023592001A5054084457 @default.
• W2023592001 hasAuthorship W2023592001A5060528721 @default.
• W2023592001 hasAuthorship W2023592001A5085768446 @default.
• W2023592001 hasConcept C12554922 @default.
• W2023592001 hasConcept C178790620 @default.
• W2023592001 hasConcept C185592680 @default.
• W2023592001 hasConcept C202751555 @default.
• W2023592001 hasConcept C2776741303 @default.
• W2023592001 hasConcept C2776986425 @default.
• W2023592001 hasConcept C2778921374 @default.
• W2023592001 hasConcept C50952357 @default.
• W2023592001 hasConcept C537181965 @default.
• W2023592001 hasConcept C55493867 @default.
• W2023592001 hasConcept C79879829 @default.
• W2023592001 hasConcept C86803240 @default.
• W2023592001 hasConcept C98274493 @default.
• W2023592001 hasConceptScore W2023592001C12554922 @default.
• W2023592001 hasConceptScore W2023592001C178790620 @default.
• W2023592001 hasConceptScore W2023592001C185592680 @default.
• W2023592001 hasConceptScore W2023592001C202751555 @default.
• W2023592001 hasConceptScore W2023592001C2776741303 @default.
• W2023592001 hasConceptScore W2023592001C2776986425 @default.
• W2023592001 hasConceptScore W2023592001C2778921374 @default.
• W2023592001 hasConceptScore W2023592001C50952357 @default.
• W2023592001 hasConceptScore W2023592001C537181965 @default.
• W2023592001 hasConceptScore W2023592001C55493867 @default.
• W2023592001 hasConceptScore W2023592001C79879829 @default.
• W2023592001 hasConceptScore W2023592001C86803240 @default.

• next