FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023592074> ?p ?o ?g. }

• W2023592074 endingPage "119" @default.
• W2023592074 startingPage "115" @default.
• W2023592074 abstract "<b><i>Objective:</i></b> To explore the relationship between intraepidermal nerve fiber (IENF) density in HIV-associated sensory neuropathy (HIV-SN) to measurements of neuropathy severity and progression of HIV disease. <b><i>Background:</i></b> SN affects 30% of individuals with AIDS, and treatment is often ineffective. Recombinant human nerve growth factor (rhNGF) has been proposed as a trophic factor for unmyelinated nerve fibers injured in HIV-SN, and a clinical trial has recently concluded. Skin biopsy with IENF density determination has emerged as a diagnostic test for patients with small-fiber sensory neuropathy. <b><i>Methods:</i></b> Sixty-two of the 270 patients with HIV-SN who participated in the trial of rhNGF were included in a substudy examining epidermal nerve fibers. IENF density was compared with neuropathic pain intensity (measured with the Gracely Pain Scale), patient and physician global pain assessments, quantitative sensory testing, CD4 counts, and plasma HIV RNA levels both at baseline and at conclusion of the placebo-controlled phase. <b><i>Results:</i></b> IENF density was inversely correlated with neuropathic pain as measured by patient (<i>p</i> = 0.004) and physician (<i>p</i> = 0.05) global pain assessments, but not using the Gracely Pain Scale. Decreased IENF density at the distal leg was associated with lower CD4 counts and higher plasma HIV RNA levels. IENF density measurements were stable over time. <b><i>Conclusions:</i></b> IENF loss at the distal leg is associated with increased neuropathic pain, lower CD4 counts, and higher plasma viral load in HIV-SN. The robustness of the longitudinal measurement of IENF density supports its use in future longitudinal studies and clinical trials." @default.
• W2023592074 created "2016-06-24" @default.
• W2023592074 creator A5004917961 @default.
• W2023592074 creator A5008207613 @default.
• W2023592074 creator A5014686861 @default.
• W2023592074 creator A5015669455 @default.
• W2023592074 creator A5017422398 @default.
• W2023592074 creator A5038368249 @default.
• W2023592074 creator A5042232387 @default.
• W2023592074 creator A5053502830 @default.
• W2023592074 creator A5059878540 @default.
• W2023592074 creator A5066975903 @default.
• W2023592074 creator A5070549767 @default.
• W2023592074 creator A5082591664 @default.
• W2023592074 creator A5084581862 @default.
• W2023592074 creator A5088660280 @default.
• W2023592074 date "2002-01-08" @default.
• W2023592074 modified "2023-10-18" @default.
• W2023592074 title "Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy" @default.
• W2023592074 cites W1505464021 @default.
• W2023592074 cites W1582090951 @default.
• W2023592074 cites W1617355594 @default.
• W2023592074 cites W1964464624 @default.
• W2023592074 cites W1988130989 @default.
• W2023592074 cites W2024864390 @default.
• W2023592074 cites W2034760164 @default.
• W2023592074 cites W2036738390 @default.
• W2023592074 cites W2056440241 @default.
• W2023592074 cites W2081957638 @default.
• W2023592074 cites W2095742978 @default.
• W2023592074 cites W2133316133 @default.
• W2023592074 cites W2140969998 @default.
• W2023592074 cites W2142402689 @default.
• W2023592074 cites W2142672496 @default.
• W2023592074 cites W2169704215 @default.
• W2023592074 cites W2213412330 @default.
• W2023592074 doi "https://doi.org/10.1212/wnl.58.1.115" @default.
• W2023592074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11781415" @default.
• W2023592074 hasPublicationYear "2002" @default.
• W2023592074 type Work @default.
• W2023592074 sameAs 2023592074 @default.
• W2023592074 citedByCount "277" @default.
• W2023592074 countsByYear W20235920742012 @default.
• W2023592074 countsByYear W20235920742013 @default.
• W2023592074 countsByYear W20235920742014 @default.
• W2023592074 countsByYear W20235920742015 @default.
• W2023592074 countsByYear W20235920742016 @default.
• W2023592074 countsByYear W20235920742017 @default.
• W2023592074 countsByYear W20235920742018 @default.
• W2023592074 countsByYear W20235920742019 @default.
• W2023592074 countsByYear W20235920742020 @default.
• W2023592074 countsByYear W20235920742021 @default.
• W2023592074 countsByYear W20235920742022 @default.
• W2023592074 countsByYear W20235920742023 @default.
• W2023592074 crossrefType "journal-article" @default.
• W2023592074 hasAuthorship W2023592074A5004917961 @default.
• W2023592074 hasAuthorship W2023592074A5008207613 @default.
• W2023592074 hasAuthorship W2023592074A5014686861 @default.
• W2023592074 hasAuthorship W2023592074A5015669455 @default.
• W2023592074 hasAuthorship W2023592074A5017422398 @default.
• W2023592074 hasAuthorship W2023592074A5038368249 @default.
• W2023592074 hasAuthorship W2023592074A5042232387 @default.
• W2023592074 hasAuthorship W2023592074A5053502830 @default.
• W2023592074 hasAuthorship W2023592074A5059878540 @default.
• W2023592074 hasAuthorship W2023592074A5066975903 @default.
• W2023592074 hasAuthorship W2023592074A5070549767 @default.
• W2023592074 hasAuthorship W2023592074A5082591664 @default.
• W2023592074 hasAuthorship W2023592074A5084581862 @default.
• W2023592074 hasAuthorship W2023592074A5088660280 @default.
• W2023592074 hasConcept C105702510 @default.
• W2023592074 hasConcept C126322002 @default.
• W2023592074 hasConcept C134018914 @default.
• W2023592074 hasConcept C142724271 @default.
• W2023592074 hasConcept C15744967 @default.
• W2023592074 hasConcept C180747234 @default.
• W2023592074 hasConcept C204787440 @default.
• W2023592074 hasConcept C27081682 @default.
• W2023592074 hasConcept C2775934546 @default.
• W2023592074 hasConcept C2776823239 @default.
• W2023592074 hasConcept C2777107010 @default.
• W2023592074 hasConcept C2779178840 @default.
• W2023592074 hasConcept C2779901536 @default.
• W2023592074 hasConcept C2780439664 @default.
• W2023592074 hasConcept C2909026353 @default.
• W2023592074 hasConcept C42219234 @default.
• W2023592074 hasConcept C555293320 @default.
• W2023592074 hasConcept C71924100 @default.
• W2023592074 hasConcept C90924648 @default.
• W2023592074 hasConcept C94487597 @default.
• W2023592074 hasConceptScore W2023592074C105702510 @default.
• W2023592074 hasConceptScore W2023592074C126322002 @default.
• W2023592074 hasConceptScore W2023592074C134018914 @default.
• W2023592074 hasConceptScore W2023592074C142724271 @default.
• W2023592074 hasConceptScore W2023592074C15744967 @default.
• W2023592074 hasConceptScore W2023592074C180747234 @default.
• W2023592074 hasConceptScore W2023592074C204787440 @default.
• W2023592074 hasConceptScore W2023592074C27081682 @default.
• W2023592074 hasConceptScore W2023592074C2775934546 @default.

• next