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• W2023592326 abstract "1. The steady-state and kinetic characteristics of the processes of activation and inactivation of the Na(+) permeability, P(Na), were measured in cut skeletal muscle fibres from Rana temporaria under voltage-clamp conditions.2. The specific resistance, r(ss), in series with the surface sarcolemma, was estimated as 6 Omega cm(2) by measuring the initial value of the membrane potential transient in response to current pulses under current-clamp conditions. To reduce the error in the potential across the sarcolemma introduced by r(ss), Na(+) currents were recorded using positive feed-back compensation, in the presence of tetrodotoxin (2.4-5 nm).3. P(Na)(t) was fitted with m(3)h kinetics assuming a voltage-dependent delay, deltat, to the start of the activation process.4. The P(Na)-V(p) curve exhibited saturation at potentials more positive than 30 mV. m(infinity), calculated as (P(Na), (infinity)/ P(Na))((1/3)) as a function of V(p), was a sigmoid curve with a mid point at -35 mV. The slope, dm(infinity)/dV(p), at this point was 0.032 mV(-1).5. Using a double-pulse protocol a non-exponential time course for the development of fast inactivation at small depolarizations was observed.6. The time constant for activation, tau(m), as a function of V(p), and tau(h) as a function of V(p), could be fitted with an approximately bell-shaped function, maximum of 430 mus at -43 mV and 925 mus at -78 mV respectively, at 15 degrees C.7. The mid-point potential of the h(infinity)-V(l) curve occurred at -58 mV, and h(infinity) approached 1 for V(1) values more negative than -103 mV.8. Using a double-pulse procedure the development of a slow inactivation of the Na(+) current was demonstrated. Its time course could be described in terms of a single exponential function, time constant equal to 0.58 s. The recovery from slow inactivation could be described by a similar exponential for recovery times smaller than 1 s." @default.
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• W2023592326 date "1982-03-01" @default.
• W2023592326 modified "2023-10-15" @default.
• W2023592326 title "Activation and inactivation characteristics of the sodium permeability in muscle fibres fromRana temporaria" @default.
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• W2023592326 doi "https://doi.org/10.1113/jphysiol.1982.sp014114" @default.
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