FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023592868> ?p ?o ?g. }

• W2023592868 endingPage "217" @default.
• W2023592868 startingPage "209" @default.
• W2023592868 abstract "Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. New BPD is characterized as having alveolar simplification. We reported previously that aryl hydrocarbon receptor (AhR) deficiency increased susceptibility to hyperoxic lung injury in adult mice, and this was associated with decreased expression of cytochrome P450 1A enzymes and increased lung inflammation. Whether AhR protects newborn mice against hyperoxia-induced alveolar simplification is unknown. Thus, we tested the hypothesis that decreased activation of the pulmonary AhR augments hyperoxia-induced alveolar simplification and lung inflammation in newborn mice. Experimental groups included one-day old wild type (WT) and AhR dysfunctional (AhRd) mice exposed to 21% O₂ (air) or 85% O₂ (hyperoxia) for 14 days. Exposure of newborn WT mice to hyperoxia resulted in increased protein, enzyme and mRNA expression of the AhR-regulated lung cytochrome P450 1A1, NAD(P)H quinone oxidoreductase-1, and microsomal glutathione S-transferase 1 enzymes, suggesting that hyperoxia increases activation of the pulmonary AhR. On the other hand, in the AhRd mice, hyperoxia induced the AhR-regulated enzymes to a lesser extent probably due to the dysfunctional AhR in these mice. Alveolar simplification and lung inflammation was increased in mice exposed to hyperoxia compared with those exposed to air, and AhRd mice were more susceptible to hyperoxia-induced alveolar simplification and lung inflammation compared with WT mice. These findings suggest that decreased activation of the pulmonary AhR in newborn AhRd mice augments hyperoxia-induced alveolar simplification and lung inflammation in these mice." @default.
• W2023592868 created "2016-06-24" @default.
• W2023592868 creator A5001364718 @default.
• W2023592868 creator A5006451102 @default.
• W2023592868 creator A5043018456 @default.
• W2023592868 creator A5055200480 @default.
• W2023592868 creator A5063079542 @default.
• W2023592868 creator A5076687485 @default.
• W2023592868 creator A5090167637 @default.
• W2023592868 date "2013-03-01" @default.
• W2023592868 modified "2023-10-16" @default.
• W2023592868 title "Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice" @default.
• W2023592868 cites W1604748982 @default.
• W2023592868 cites W1963492502 @default.
• W2023592868 cites W1965214134 @default.
• W2023592868 cites W1970760791 @default.
• W2023592868 cites W1980733086 @default.
• W2023592868 cites W1991640279 @default.
• W2023592868 cites W1993809284 @default.
• W2023592868 cites W1998622278 @default.
• W2023592868 cites W1999194263 @default.
• W2023592868 cites W2000017694 @default.
• W2023592868 cites W2000441102 @default.
• W2023592868 cites W2002314190 @default.
• W2023592868 cites W2006500041 @default.
• W2023592868 cites W2022645849 @default.
• W2023592868 cites W2028157333 @default.
• W2023592868 cites W2030607204 @default.
• W2023592868 cites W2037581573 @default.
• W2023592868 cites W2039610966 @default.
• W2023592868 cites W2044823299 @default.
• W2023592868 cites W2044944825 @default.
• W2023592868 cites W2047823578 @default.
• W2023592868 cites W2050717509 @default.
• W2023592868 cites W2054112283 @default.
• W2023592868 cites W2058266230 @default.
• W2023592868 cites W2068234607 @default.
• W2023592868 cites W2074825511 @default.
• W2023592868 cites W2075649289 @default.
• W2023592868 cites W2076569763 @default.
• W2023592868 cites W2081786869 @default.
• W2023592868 cites W2083287953 @default.
• W2023592868 cites W2084846490 @default.
• W2023592868 cites W2085592918 @default.
• W2023592868 cites W2087332917 @default.
• W2023592868 cites W2089288497 @default.
• W2023592868 cites W2112868809 @default.
• W2023592868 cites W2118894711 @default.
• W2023592868 cites W2123718444 @default.
• W2023592868 cites W2128360784 @default.
• W2023592868 cites W2133148204 @default.
• W2023592868 cites W2136687415 @default.
• W2023592868 cites W2144025980 @default.
• W2023592868 cites W2147934896 @default.
• W2023592868 cites W2150933311 @default.
• W2023592868 cites W2159396934 @default.
• W2023592868 cites W2409369869 @default.
• W2023592868 doi "https://doi.org/10.1016/j.taap.2013.01.003" @default.
• W2023592868 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3582791" @default.
• W2023592868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23337360" @default.
• W2023592868 hasPublicationYear "2013" @default.
• W2023592868 type Work @default.
• W2023592868 sameAs 2023592868 @default.
• W2023592868 citedByCount "31" @default.
• W2023592868 countsByYear W20235928682014 @default.
• W2023592868 countsByYear W20235928682015 @default.
• W2023592868 countsByYear W20235928682016 @default.
• W2023592868 countsByYear W20235928682017 @default.
• W2023592868 countsByYear W20235928682018 @default.
• W2023592868 countsByYear W20235928682019 @default.
• W2023592868 countsByYear W20235928682020 @default.
• W2023592868 countsByYear W20235928682021 @default.
• W2023592868 countsByYear W20235928682022 @default.
• W2023592868 countsByYear W20235928682023 @default.
• W2023592868 crossrefType "journal-article" @default.
• W2023592868 hasAuthorship W2023592868A5001364718 @default.
• W2023592868 hasAuthorship W2023592868A5006451102 @default.
• W2023592868 hasAuthorship W2023592868A5043018456 @default.
• W2023592868 hasAuthorship W2023592868A5055200480 @default.
• W2023592868 hasAuthorship W2023592868A5063079542 @default.
• W2023592868 hasAuthorship W2023592868A5076687485 @default.
• W2023592868 hasAuthorship W2023592868A5090167637 @default.
• W2023592868 hasBestOaLocation W20235928682 @default.
• W2023592868 hasConcept C104317684 @default.
• W2023592868 hasConcept C126322002 @default.
• W2023592868 hasConcept C134018914 @default.
• W2023592868 hasConcept C185592680 @default.
• W2023592868 hasConcept C203014093 @default.
• W2023592868 hasConcept C2776914184 @default.
• W2023592868 hasConcept C2777714996 @default.
• W2023592868 hasConcept C2778376644 @default.
• W2023592868 hasConcept C2778721537 @default.
• W2023592868 hasConcept C2779234561 @default.
• W2023592868 hasConcept C2780672939 @default.
• W2023592868 hasConcept C33594762 @default.
• W2023592868 hasConcept C54355233 @default.
• W2023592868 hasConcept C55493867 @default.
• W2023592868 hasConcept C71924100 @default.

• next