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- W2023593061 abstract "Many intracellular components are present in low copy numbers per cell and subject to feedback control. We use chemical master equations to analyze a negative feedback system where species $X$ and $S$ regulate each other's synthesis with standard intracellular kinetics. For a given number of $X$-molecules, $S$-variation can be significant. We show that this signal noise does not necessarily increase $X$-variation as previously thought but, surprisingly, can be necessary to reduce it below a Poissonian limit. The principle resembles Stochastic Resonance in that signal noise improves signal detection." @default.
- W2023593061 created "2016-06-24" @default.
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- W2023593061 date "2000-06-05" @default.
- W2023593061 modified "2023-09-30" @default.
- W2023593061 title "Random Signal Fluctuations Can Reduce Random Fluctuations in Regulated Components of Chemical Regulatory Networks" @default.
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- W2023593061 doi "https://doi.org/10.1103/physrevlett.84.5447" @default.
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