FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023594077> ?p ?o ?g. }

• W2023594077 endingPage "3258" @default.
• W2023594077 startingPage "3248" @default.
• W2023594077 abstract "Gold nanomaterials (AuNMs) have distinctive electronic and optical properties, making them ideal candidates for biological, medical, and defense applications. Therefore, it is imperative to evaluate the potential biological impact of AuNMs before employing them in any application. This study investigates two AuNMs with different aspect ratios (AR) on mediation of biological responses in the human keratinocyte cell line (HaCaT) to model potential skin exposure to these AuNMs. The cellular responses were evaluated by cell viability, reactive oxygen species (ROS) generation, alteration in gene and protein expression, and inflammatory response. Gold nanospheres, nominally 20 nm in diameter and coated with mercaptopropane sulfonate (AuNS–MPS), formed agglomerates when dispersed in cell culture media, had a large fractal dimension (Df = 2.57 ± 0.4) (i.e., tightly bound and densely packed) and were found to be nontoxic even at the highest dose of 100 μg/mL. Highly uniform, 16.7 nm diameter, and 43.8 nm long polyethylene glycol-capped gold nanorods (AuNR–PEG) also formed agglomerates when dispersed into the cell culture media. However, the agglomerates had a smaller fractal dimension (Df = 1.28 ± 0.08) (i.e., loosely bound) and were found to be cytotoxic to the HaCaT cells, with a significant decrease in cell viability occurring at 25 μg/mL and higher. Moreover, AuNR–PEG caused significant ROS production and up-regulated several genes involved in cellular stress and toxicity. These results, combined with increased levels of inflammatory and apoptotic proteins, demonstrated that the AuNR–PEG induced apoptosis. Exposure to AuNS–MPS, however, did not show any of the detrimental effects observed from the AuNR–PEG. Therefore, we conclude that shape appears to play a key role in mediating the cellular response to AuNMs." @default.
• W2023594077 created "2016-06-24" @default.
• W2023594077 creator A5002684335 @default.
• W2023594077 creator A5027725855 @default.
• W2023594077 creator A5028524328 @default.
• W2023594077 creator A5029827136 @default.
• W2023594077 creator A5031775300 @default.
• W2023594077 creator A5034448961 @default.
• W2023594077 creator A5055273606 @default.
• W2023594077 creator A5070489210 @default.
• W2023594077 creator A5089045154 @default.
• W2023594077 date "2012-02-03" @default.
• W2023594077 modified "2023-10-16" @default.
• W2023594077 title "Does Shape Matter? Bioeffects of Gold Nanomaterials in a Human Skin Cell Model" @default.
• W2023594077 cites W1963745089 @default.
• W2023594077 cites W1967850823 @default.
• W2023594077 cites W1968023303 @default.
• W2023594077 cites W1971888650 @default.
• W2023594077 cites W1975837510 @default.
• W2023594077 cites W1980290112 @default.
• W2023594077 cites W1992215904 @default.
• W2023594077 cites W1996139192 @default.
• W2023594077 cites W1996232062 @default.
• W2023594077 cites W1999087415 @default.
• W2023594077 cites W1999562731 @default.
• W2023594077 cites W2001629471 @default.
• W2023594077 cites W2003336829 @default.
• W2023594077 cites W2006777623 @default.
• W2023594077 cites W2007852606 @default.
• W2023594077 cites W2009207411 @default.
• W2023594077 cites W2011318238 @default.
• W2023594077 cites W2015680598 @default.
• W2023594077 cites W2021713080 @default.
• W2023594077 cites W2022341226 @default.
• W2023594077 cites W2025188006 @default.
• W2023594077 cites W2026408068 @default.
• W2023594077 cites W2029749273 @default.
• W2023594077 cites W2034920439 @default.
• W2023594077 cites W2035404671 @default.
• W2023594077 cites W2035901751 @default.
• W2023594077 cites W2041308432 @default.
• W2023594077 cites W2041742565 @default.
• W2023594077 cites W204512410 @default.
• W2023594077 cites W2048939436 @default.
• W2023594077 cites W2055944585 @default.
• W2023594077 cites W2057910069 @default.
• W2023594077 cites W2059086967 @default.
• W2023594077 cites W2059205969 @default.
• W2023594077 cites W2063172840 @default.
• W2023594077 cites W2068782113 @default.
• W2023594077 cites W2069085012 @default.
• W2023594077 cites W2070258900 @default.
• W2023594077 cites W2072236397 @default.
• W2023594077 cites W2074052341 @default.
• W2023594077 cites W2076895064 @default.
• W2023594077 cites W2077887473 @default.
• W2023594077 cites W2078325166 @default.
• W2023594077 cites W2080008975 @default.
• W2023594077 cites W2081572333 @default.
• W2023594077 cites W2082132387 @default.
• W2023594077 cites W2082930584 @default.
• W2023594077 cites W2083217909 @default.
• W2023594077 cites W2083826459 @default.
• W2023594077 cites W2084186494 @default.
• W2023594077 cites W2085006519 @default.
• W2023594077 cites W2096662766 @default.
• W2023594077 cites W2107519814 @default.
• W2023594077 cites W2108611432 @default.
• W2023594077 cites W2111812837 @default.
• W2023594077 cites W2113999599 @default.
• W2023594077 cites W2117326659 @default.
• W2023594077 cites W2117630026 @default.
• W2023594077 cites W2125123295 @default.
• W2023594077 cites W2129569338 @default.
• W2023594077 cites W2131580401 @default.
• W2023594077 cites W2134499051 @default.
• W2023594077 cites W2135890357 @default.
• W2023594077 cites W2137335948 @default.
• W2023594077 cites W2140537016 @default.
• W2023594077 cites W2142947568 @default.
• W2023594077 cites W2143464311 @default.
• W2023594077 cites W2160045751 @default.
• W2023594077 cites W2312662255 @default.
• W2023594077 cites W2322249900 @default.
• W2023594077 cites W2073099720 @default.
• W2023594077 doi "https://doi.org/10.1021/la204081m" @default.
• W2023594077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22242624" @default.
• W2023594077 hasPublicationYear "2012" @default.
• W2023594077 type Work @default.
• W2023594077 sameAs 2023594077 @default.
• W2023594077 citedByCount "112" @default.
• W2023594077 countsByYear W20235940772012 @default.
• W2023594077 countsByYear W20235940772013 @default.
• W2023594077 countsByYear W20235940772014 @default.
• W2023594077 countsByYear W20235940772015 @default.
• W2023594077 countsByYear W20235940772016 @default.
• W2023594077 countsByYear W20235940772017 @default.
• W2023594077 countsByYear W20235940772018 @default.

• next