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- W2023595099 abstract "The mycotoxins, penicillic acid and patulin, were found to inhibit aldolase non-competitively in vitro with inhibition constants (K i) of 9·0 × 10 −6m and 1·3 × 10 −5m, respectively. The inhibition was not prevented by the addition of cysteine to the assay system. The cysteine adduct of penicillic acid was comparable to the original mycotoxin in its inhibition of aldolase. However, less inhibition was observed when the cysteine adduct of patulin was used. Chemical analyses of the inactivated enzyme revealed that with each mycotoxin covalent interaction with -SH and -NH 2 groups in the protein had occurred. On a constatéque deux mycotoxines, l'acide pénicillique et la patuline, inhibent l'aldolase in vitro. Ces inhibitions sont non-compétitives et les constantes d'inhibition (K i) respectives sont 9,0 × 10 −6m et 1,3, × 10 −5m. L'addition de cystéine au milieu de détermination n'a pas empeˆchél'inhibition. Le systéme cystéine + acide pénicillique a inhibél'aldolase de fa çon comparableàcelle de la mycotoxine originelle, mais on a observémoins d'inhibition avec le système cystéine + patuline. Les analyses chimiques de l'enzyme inactivéont révéléqu'il s'était produit, avec chaque mycotoxine, une interaction covalente avec les radicaux -SH et -NH 2 de la protéine. Die Mycotoxine Penicillinsäure und Patulin hemmen in vitro nicht kompetitiv die Aldolase in vitro mit der Hemmkonstante (K i) 9,0 × 10 −6m bzw. 1,3 × 10 −5m. Die Hemmung wurde durch die Zugabe von Cystein zu dem Versuchsansatz nicht verhindert. Das Cysteinanlargerungsprodukt von Penicillinsäure war in der Inhibierung von Aldolase mir dem ursprünglichen Mycotoxin vergleichbar. Es wurde jedoch eine geringere Inhibition beobachtet, wenn das Cysteinaddukt von Patulin verwendet wurde. Die chemischen Analysen des inaktivierten Enzyms zeigen, dass mit jedem Mycotoxin kovalente Wechselwirkungen mit SH- und NH 2-Gruppen in dem Protein aufgetreten waren." @default.
- W2023595099 created "2016-06-24" @default.
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- W2023595099 date "1973-12-01" @default.
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- W2023595099 title "Inhibition of muscle aldolase by penicillic acid and patulin In vitro" @default.
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- W2023595099 doi "https://doi.org/10.1016/0015-6264(73)90226-5" @default.
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