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• W2023595346 abstract "The ability to form gigaseals is essential for patch clamp, but the physics of how membranes form gigaseals cannot analyzed spectroscopically because the seal region is too thin. However, ion channels located in the seal can produce measureable currents that contribute to patch recordings and potentially their kinetics can elucidate properties of the seal. We modeled the seal using a finite element simulation of the 2D cable equation with the membrane (resistance and capacitance) as one side and nonconductive/noncapacitative glass as the other, and a resistive and diffusive aqueous solution in between." @default.
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• W2023595346 date "2011-02-01" @default.
• W2023595346 modified "2023-09-29" @default.
• W2023595346 title "Ion Channel Currents in the Gigaseal are Visible and have Altered Kinetics: A Finite Element Model" @default.
• W2023595346 doi "https://doi.org/10.1016/j.bpj.2010.12.710" @default.
• W2023595346 hasPublicationYear "2011" @default.
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