Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023595660> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2023595660 endingPage "301" @default.
- W2023595660 startingPage "298" @default.
- W2023595660 abstract "The biochemical mechanism of lymphocyte dysfunction with adenosine deaminase deficiency has been investigated using cultured phytohemagglutinin stimulated normal peripheral blood lymphocytes and the adenosine deaminase (ADA) inhibitor 2′-deoxycoformycin. The addition of deoxyadenosine to ADA-inhibited (but not to uninhibited) cells generated increased dATP pools (up to 50-fold greater than controls) and depressed the mitogen response. dATP Accumulation was accompanied by depletion of the other three deoxynucleoside triphosphate (dNTP) pools (dTTP, dCTP, and dGTP). Suppression of the mitogen response could be prevented (“reversed”) to 90% of control levels by the addition of deoxynucleoside precursors for the depleted dNTPs at the initiation of mitogen stimulation. “Reversal” restored the dTTP and possibly the dGTP pools. Thus the mechanism of toxicity in this model appears to be inhibition of ribonucleotide reductase by massive accumulation of dATP, resulting in starvation for the other three deoxyribonucleoside triphosphates. “Reversibility” of this toxicity by providing sources for the missing three deoxynucleoside triphosphates argues for ribonucleotide reductase inhibition rather than other mechanisms of deoxyadenosine toxicity in this model." @default.
- W2023595660 created "2016-06-24" @default.
- W2023595660 creator A5036852235 @default.
- W2023595660 creator A5065366799 @default.
- W2023595660 date "1959-12-01" @default.
- W2023595660 modified "2023-10-17" @default.
- W2023595660 title "X-ray inhibition of enzyme changes associated with the DNA synthesis of liver regeneration" @default.
- W2023595660 cites W1525765291 @default.
- W2023595660 cites W2041918018 @default.
- W2023595660 cites W2327005643 @default.
- W2023595660 doi "https://doi.org/10.1016/0006-291x(59)90042-7" @default.
- W2023595660 hasPublicationYear "1959" @default.
- W2023595660 type Work @default.
- W2023595660 sameAs 2023595660 @default.
- W2023595660 citedByCount "33" @default.
- W2023595660 countsByYear W20235956602016 @default.
- W2023595660 crossrefType "journal-article" @default.
- W2023595660 hasAuthorship W2023595660A5036852235 @default.
- W2023595660 hasAuthorship W2023595660A5065366799 @default.
- W2023595660 hasConcept C104292427 @default.
- W2023595660 hasConcept C104317684 @default.
- W2023595660 hasConcept C153911025 @default.
- W2023595660 hasConcept C181199279 @default.
- W2023595660 hasConcept C185592680 @default.
- W2023595660 hasConcept C2776123222 @default.
- W2023595660 hasConcept C2776991684 @default.
- W2023595660 hasConcept C2777108182 @default.
- W2023595660 hasConcept C2780636463 @default.
- W2023595660 hasConcept C2909627636 @default.
- W2023595660 hasConcept C2910277799 @default.
- W2023595660 hasConcept C34628245 @default.
- W2023595660 hasConcept C4710235 @default.
- W2023595660 hasConcept C552990157 @default.
- W2023595660 hasConcept C55493867 @default.
- W2023595660 hasConcept C64241487 @default.
- W2023595660 hasConcept C86803240 @default.
- W2023595660 hasConceptScore W2023595660C104292427 @default.
- W2023595660 hasConceptScore W2023595660C104317684 @default.
- W2023595660 hasConceptScore W2023595660C153911025 @default.
- W2023595660 hasConceptScore W2023595660C181199279 @default.
- W2023595660 hasConceptScore W2023595660C185592680 @default.
- W2023595660 hasConceptScore W2023595660C2776123222 @default.
- W2023595660 hasConceptScore W2023595660C2776991684 @default.
- W2023595660 hasConceptScore W2023595660C2777108182 @default.
- W2023595660 hasConceptScore W2023595660C2780636463 @default.
- W2023595660 hasConceptScore W2023595660C2909627636 @default.
- W2023595660 hasConceptScore W2023595660C2910277799 @default.
- W2023595660 hasConceptScore W2023595660C34628245 @default.
- W2023595660 hasConceptScore W2023595660C4710235 @default.
- W2023595660 hasConceptScore W2023595660C552990157 @default.
- W2023595660 hasConceptScore W2023595660C55493867 @default.
- W2023595660 hasConceptScore W2023595660C64241487 @default.
- W2023595660 hasConceptScore W2023595660C86803240 @default.
- W2023595660 hasIssue "6" @default.
- W2023595660 hasLocation W20235956601 @default.
- W2023595660 hasOpenAccess W2023595660 @default.
- W2023595660 hasPrimaryLocation W20235956601 @default.
- W2023595660 hasRelatedWork W1507939041 @default.
- W2023595660 hasRelatedWork W2008626947 @default.
- W2023595660 hasRelatedWork W2025096553 @default.
- W2023595660 hasRelatedWork W2059470610 @default.
- W2023595660 hasRelatedWork W2085475872 @default.
- W2023595660 hasRelatedWork W2414758805 @default.
- W2023595660 hasRelatedWork W2418823632 @default.
- W2023595660 hasRelatedWork W2479174904 @default.
- W2023595660 hasRelatedWork W4246725428 @default.
- W2023595660 hasRelatedWork W2740586141 @default.
- W2023595660 hasVolume "1" @default.
- W2023595660 isParatext "false" @default.
- W2023595660 isRetracted "false" @default.
- W2023595660 magId "2023595660" @default.
- W2023595660 workType "article" @default.