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- W2023596843 abstract "The intragastric host-mediated assay (h.m.a.) was devised and carried out with a view to assessing the formation of direct mutagens in the gastrointestinal tract of mammals. The h.m.a. consists in the injection of nitrosable compounds, NaNO 2 and cells of the yeast S. pombe , by gavage into the animals' stomachs and in the recovery of the target cells from the faeces for mutation-induction analysis. Methylurea was chosen as a model nitrosable compound, and the effects of nitrosation modulators such as ascorbic acid and thiocyanate were studied. Cimetidine, a drug nitrosable in vitro, was tested with the system. Positive results were obtained only at very large doses and in artificially produced low pH. The new host-mediated assay seems to be efficient in revealing the formation, in vivo, of direct, short-living mutagens." @default.
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- W2023596843 date "1983-02-01" @default.
- W2023596843 modified "2023-10-07" @default.
- W2023596843 title "The intragastric host-mediated assay for the assessment of the formation of direct mutagens in vivo" @default.
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- W2023596843 doi "https://doi.org/10.1016/0165-1161(83)90238-8" @default.
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