FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023598998> ?p ?o ?g. }

• W2023598998 endingPage "199" @default.
• W2023598998 startingPage "190" @default.
• W2023598998 abstract "Depletion of proline from insulin, hydrocortisone, and prolactin-containing medium prior to incubating virgin mouse mammary explants prevents both DNA synthesis and functional differentiation in the mammary epithelial cells; however, DNA synthesis in the mammary stroma and total incorporation of radioactive amino acids into total protein appears to continue without hindrance. Removal of glycine instead of proline had no deleterious effect on either DNA replication in the hormone-stimulated epithelium or in its functional differentiation. Functional differentiation was determined by the induction of casein and α-lactalbumin synthesis in the insulin, hydrocortisone, and prolactin (IFPrl)-treated explant cultures. As a control, the induction of mouse mammary tumor virus (MMTV) gene expression, a cortiocosteroid-regulated function, was also measured. Neither the absence of proline or glycine prevented the glucocorticoid stimulation of MMTV gene expression. In contrast to mammary tissue from virgin mice, explants from nonpregnant primiparous mice responded fully to IFPrl stimulation with respect to DNA, casein, and α-lactalbumin synthesis in medium depleted of proline. These data suggest that the uncommitted epithelium of virgin mouse mammary glands requires the presence of exogenous proline in order to respond to lactogenic hormonal signals. We have demonstrated earlier that DNA synthesis is a prerequisite of functional differentiation in virgin mouse mammary explants (Smith and Vonderhaar, 1981, Dev. Biol., 88:167–179; Vonderhaar and Smith, 1982, J. Cell Sci, 53:97–114), although cytological differentiation proceeded unencumbered in explants prevented from synthesizing DNA. Here, without proline, neither cytological nor functional differentiation can be induced; this suggests that proline provides an essential metabolic interlock in the acquisition of lactogenic hormone responsiveness in uncommitted mouse mammary tissue." @default.
• W2023598998 created "2016-06-24" @default.
• W2023598998 creator A5082987275 @default.
• W2023598998 date "1987-05-01" @default.
• W2023598998 modified "2023-09-27" @default.
• W2023598998 title "Functional differentiation of virgin mouse mammary epithelium in explant culture is dependent upon extracellular proline" @default.
• W2023598998 cites W1598101055 @default.
• W2023598998 cites W1889902218 @default.
• W2023598998 cites W1966391110 @default.
• W2023598998 cites W1981305966 @default.
• W2023598998 cites W1982956085 @default.
• W2023598998 cites W1987612712 @default.
• W2023598998 cites W1990440707 @default.
• W2023598998 cites W1994923158 @default.
• W2023598998 cites W2025868595 @default.
• W2023598998 cites W2044163321 @default.
• W2023598998 cites W2045959446 @default.
• W2023598998 cites W2051651746 @default.
• W2023598998 cites W2091729696 @default.
• W2023598998 cites W2093048417 @default.
• W2023598998 cites W2094915902 @default.
• W2023598998 cites W2101517199 @default.
• W2023598998 cites W2115762919 @default.
• W2023598998 cites W2127313965 @default.
• W2023598998 cites W2147108228 @default.
• W2023598998 cites W2153629400 @default.
• W2023598998 cites W2154192600 @default.
• W2023598998 cites W2161504937 @default.
• W2023598998 cites W2197316737 @default.
• W2023598998 doi "https://doi.org/10.1002/jcp.1041310208" @default.
• W2023598998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3034921" @default.
• W2023598998 hasPublicationYear "1987" @default.
• W2023598998 type Work @default.
• W2023598998 sameAs 2023598998 @default.
• W2023598998 citedByCount "20" @default.
• W2023598998 countsByYear W20235989982016 @default.
• W2023598998 countsByYear W20235989982017 @default.
• W2023598998 countsByYear W20235989982020 @default.
• W2023598998 crossrefType "journal-article" @default.
• W2023598998 hasAuthorship W2023598998A5082987275 @default.
• W2023598998 hasConcept C104317684 @default.
• W2023598998 hasConcept C126322002 @default.
• W2023598998 hasConcept C134018914 @default.
• W2023598998 hasConcept C148738053 @default.
• W2023598998 hasConcept C153911025 @default.
• W2023598998 hasConcept C157890192 @default.
• W2023598998 hasConcept C202751555 @default.
• W2023598998 hasConcept C2779064019 @default.
• W2023598998 hasConcept C2779777497 @default.
• W2023598998 hasConcept C2779815552 @default.
• W2023598998 hasConcept C515207424 @default.
• W2023598998 hasConcept C529295009 @default.
• W2023598998 hasConcept C54355233 @default.
• W2023598998 hasConcept C552990157 @default.
• W2023598998 hasConcept C55493867 @default.
• W2023598998 hasConcept C64241487 @default.
• W2023598998 hasConcept C71315377 @default.
• W2023598998 hasConcept C71924100 @default.
• W2023598998 hasConcept C86803240 @default.
• W2023598998 hasConcept C95444343 @default.
• W2023598998 hasConceptScore W2023598998C104317684 @default.
• W2023598998 hasConceptScore W2023598998C126322002 @default.
• W2023598998 hasConceptScore W2023598998C134018914 @default.
• W2023598998 hasConceptScore W2023598998C148738053 @default.
• W2023598998 hasConceptScore W2023598998C153911025 @default.
• W2023598998 hasConceptScore W2023598998C157890192 @default.
• W2023598998 hasConceptScore W2023598998C202751555 @default.
• W2023598998 hasConceptScore W2023598998C2779064019 @default.
• W2023598998 hasConceptScore W2023598998C2779777497 @default.
• W2023598998 hasConceptScore W2023598998C2779815552 @default.
• W2023598998 hasConceptScore W2023598998C515207424 @default.
• W2023598998 hasConceptScore W2023598998C529295009 @default.
• W2023598998 hasConceptScore W2023598998C54355233 @default.
• W2023598998 hasConceptScore W2023598998C552990157 @default.
• W2023598998 hasConceptScore W2023598998C55493867 @default.
• W2023598998 hasConceptScore W2023598998C64241487 @default.
• W2023598998 hasConceptScore W2023598998C71315377 @default.
• W2023598998 hasConceptScore W2023598998C71924100 @default.
• W2023598998 hasConceptScore W2023598998C86803240 @default.
• W2023598998 hasConceptScore W2023598998C95444343 @default.
• W2023598998 hasIssue "2" @default.
• W2023598998 hasLocation W20235989981 @default.
• W2023598998 hasLocation W20235989982 @default.
• W2023598998 hasOpenAccess W2023598998 @default.
• W2023598998 hasPrimaryLocation W20235989981 @default.
• W2023598998 hasRelatedWork W1966625438 @default.
• W2023598998 hasRelatedWork W1970823640 @default.
• W2023598998 hasRelatedWork W1972051303 @default.
• W2023598998 hasRelatedWork W1989173141 @default.
• W2023598998 hasRelatedWork W1990399071 @default.
• W2023598998 hasRelatedWork W2035021492 @default.
• W2023598998 hasRelatedWork W2060076556 @default.
• W2023598998 hasRelatedWork W2093676636 @default.
• W2023598998 hasRelatedWork W2120307014 @default.
• W2023598998 hasRelatedWork W2121446313 @default.
• W2023598998 hasVolume "131" @default.
• W2023598998 isParatext "false" @default.
• W2023598998 isRetracted "false" @default.

• next