Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023600708> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2023600708 endingPage "74" @default.
- W2023600708 startingPage "61" @default.
- W2023600708 abstract "Studies in other laboratories have provided evidence that the interleukin-2 (IL2) signaling pathway in lymphocytes includes essential, serine proteases. Since the anticholinesterase (antiCHE) insecticides are potent serine hydrolase (esterase and protease) inhibitors, we assessed the ability of carbaryl (CA, a widely used antiCHE insecticide) and α-naphthol (NA, a major metabolite of carbaryl) to modulate IL2-driven proliferation of large granular lymphocytes (LGL) purified from human peripheral blood. These cells express nearly all of the natural killer (NK) activity of human peripheral blood. NK cells are normal lymphocytes that respond to IL2 by proliferating and increasing their tumoricidal activity on a per cell basis. Cultures of purified LGL, initiated in the presence of human recombinant IL2, were harvested on culture Day 4, then proliferation was measured as [3H]thymidine incorporation. When added only at the time cultures were initiated, CA inhibited incorporation 10–32%, 35–53%, and 54–57% at 0.5, 5.0, and 50 μm, respectively. In contrast, NA had no effect at 0.5 and 5.0 μm, but was inhibitory (16–17%) at 50 μm. Reexposure to CA or NA, during the incorporation assay, had little effect on the observed inhibition profiles. Chemically induced changes in cell number during an 8-day culture period reflected the chemically induced changes in [3H]thymidine incorporation. Neither CA nor NA produced cell death. Quantitation of both CA and NA by HPLC indicated a rapid loss of CA (ca. 95% in 24 hr) and a much slower loss of NA from the culture medium. CA inhibited human LGL proliferation at concentrations producing little or no inhibition of serum CHE, an indicator of exposure to antiCHE insecticides." @default.
- W2023600708 created "2016-06-24" @default.
- W2023600708 creator A5068707910 @default.
- W2023600708 date "1991-07-01" @default.
- W2023600708 modified "2023-09-26" @default.
- W2023600708 title "Modulation of interleukin-2-driven proliferation of human large granular lymphocytes by carbaryl, an anticholinesterase insecticide*1, *2" @default.
- W2023600708 cites W1600703430 @default.
- W2023600708 cites W1924519659 @default.
- W2023600708 cites W1969236043 @default.
- W2023600708 cites W1976732884 @default.
- W2023600708 cites W1988989251 @default.
- W2023600708 cites W1995189245 @default.
- W2023600708 cites W1996317197 @default.
- W2023600708 cites W2000000994 @default.
- W2023600708 cites W2018742597 @default.
- W2023600708 cites W2045948242 @default.
- W2023600708 cites W2048915034 @default.
- W2023600708 cites W2053798662 @default.
- W2023600708 cites W2069512731 @default.
- W2023600708 cites W2079756272 @default.
- W2023600708 cites W2080528197 @default.
- W2023600708 cites W2088144373 @default.
- W2023600708 cites W2089567287 @default.
- W2023600708 cites W2161082695 @default.
- W2023600708 cites W2184536664 @default.
- W2023600708 cites W2416067931 @default.
- W2023600708 cites W3112457990 @default.
- W2023600708 doi "https://doi.org/10.1016/0272-0590(91)90239-z" @default.
- W2023600708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1916080" @default.
- W2023600708 hasPublicationYear "1991" @default.
- W2023600708 type Work @default.
- W2023600708 sameAs 2023600708 @default.
- W2023600708 citedByCount "11" @default.
- W2023600708 countsByYear W20236007082013 @default.
- W2023600708 crossrefType "journal-article" @default.
- W2023600708 hasAuthorship W2023600708A5068707910 @default.
- W2023600708 hasConcept C153911025 @default.
- W2023600708 hasConcept C161176658 @default.
- W2023600708 hasConcept C181199279 @default.
- W2023600708 hasConcept C182220744 @default.
- W2023600708 hasConcept C185592680 @default.
- W2023600708 hasConcept C202751555 @default.
- W2023600708 hasConcept C2776051353 @default.
- W2023600708 hasConcept C2776714187 @default.
- W2023600708 hasConcept C2777108182 @default.
- W2023600708 hasConcept C2777261171 @default.
- W2023600708 hasConcept C2777371288 @default.
- W2023600708 hasConcept C2777807008 @default.
- W2023600708 hasConcept C54355233 @default.
- W2023600708 hasConcept C55493867 @default.
- W2023600708 hasConcept C62112901 @default.
- W2023600708 hasConcept C6557445 @default.
- W2023600708 hasConcept C81885089 @default.
- W2023600708 hasConcept C86803240 @default.
- W2023600708 hasConceptScore W2023600708C153911025 @default.
- W2023600708 hasConceptScore W2023600708C161176658 @default.
- W2023600708 hasConceptScore W2023600708C181199279 @default.
- W2023600708 hasConceptScore W2023600708C182220744 @default.
- W2023600708 hasConceptScore W2023600708C185592680 @default.
- W2023600708 hasConceptScore W2023600708C202751555 @default.
- W2023600708 hasConceptScore W2023600708C2776051353 @default.
- W2023600708 hasConceptScore W2023600708C2776714187 @default.
- W2023600708 hasConceptScore W2023600708C2777108182 @default.
- W2023600708 hasConceptScore W2023600708C2777261171 @default.
- W2023600708 hasConceptScore W2023600708C2777371288 @default.
- W2023600708 hasConceptScore W2023600708C2777807008 @default.
- W2023600708 hasConceptScore W2023600708C54355233 @default.
- W2023600708 hasConceptScore W2023600708C55493867 @default.
- W2023600708 hasConceptScore W2023600708C62112901 @default.
- W2023600708 hasConceptScore W2023600708C6557445 @default.
- W2023600708 hasConceptScore W2023600708C81885089 @default.
- W2023600708 hasConceptScore W2023600708C86803240 @default.
- W2023600708 hasIssue "1" @default.
- W2023600708 hasLocation W20236007081 @default.
- W2023600708 hasLocation W20236007082 @default.
- W2023600708 hasOpenAccess W2023600708 @default.
- W2023600708 hasPrimaryLocation W20236007081 @default.
- W2023600708 hasRelatedWork W116031781 @default.
- W2023600708 hasRelatedWork W1976608269 @default.
- W2023600708 hasRelatedWork W2006002595 @default.
- W2023600708 hasRelatedWork W2023600708 @default.
- W2023600708 hasRelatedWork W2027241294 @default.
- W2023600708 hasRelatedWork W2158369850 @default.
- W2023600708 hasRelatedWork W2315375821 @default.
- W2023600708 hasRelatedWork W2491451478 @default.
- W2023600708 hasRelatedWork W2566267702 @default.
- W2023600708 hasRelatedWork W2182658384 @default.
- W2023600708 hasVolume "17" @default.
- W2023600708 isParatext "false" @default.
- W2023600708 isRetracted "false" @default.
- W2023600708 magId "2023600708" @default.
- W2023600708 workType "article" @default.