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- W2023602851 abstract "This chapter discusses agonists for EP2, EP4, FP, DP, EP1, EP3, and EP4. Prostaglandins (PGs) are a class of naturally occurring hormone-like substances. PGs are derived from 20-carbon essential fatty acid lipids and as a result possess a highly oxygenated C20 backbone. They are produced in response to various stimuli in cells throughout the body and are synthesized, released and then act primarily in the vicinity of their formation. The prostanoid family of receptors includes G protein-coupled receptors with seven transmembrane domains which are ∼20–30% homologous within the family. The structures, properties and function of PG receptors have been extensively reviewed. In the early 1980s a non-definitive but “working hypothesis” classification was proposed for DP, EP, FP, IP and TP receptors according to the binding affinities, potencies and selectivities of endogenous PGD2, PGE2, PGF2α, PGI2 and TxA2. Additional pharmacological studies and molecular biology techniques later corroborated this classification and also assisted in subdivision of the Prostaglandin E (EP)-receptor into EP1, EP2, EP3 and EP4. Further use of molecular biology led to development of single receptor cell-based assays and advanced the understanding of PG pharmacology, thus promoting a revival in PG biological utilities." @default.
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- W2023602851 date "1966-12-01" @default.
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- W2023602851 title "Determination of the origin of 9-keto-15-hydroxy-10, 13-prostadienoic acid by a double-labeling technique" @default.
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- W2023602851 doi "https://doi.org/10.1016/0005-2760(66)90052-x" @default.
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