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- W2023603014 abstract "Activationofgrowthfactorandhormonalsignallingpathways� canplaycriticalrolesinthedevelopmentandprogressionof� manycancers.�Identifyingwhichpathwaysareoverexpressed� withintumoursmayhelpimplicateputativepathwaysthatare� drivinggrowthandsurvivalandindicatepotentialtherapeutic� targets. InthisissueofOnkOlOgie,� Anandcolleaguesreporta� studydescribingassociationsbetweenexpressionlevelsofin- sulin-likegrowthfactors�(IGFs)�andtheirreceptorswithma- lignancyinovariancancer�(1).�Theyshowthathigherlevelsof� mRNAexpressionofbothIGF-IandIGF-IRwerepresent� inmalignantcomparedtobenigndiseaseandthiswasmore� evidentinpre-menopausalthanpost-menopausalwomen.� BothIGF-IandIGF-IRexpressionwereincreasedinad- vanced�(stageIII/IV)�cancercomparedtoearlydiseaseandin� poorlydifferentiatedtumourscomparedtowelldifferentiated� tumours.�Oestrogenreceptor�α�(ERα)�expressionlevelswere� alsosignificantlyhigherinmalignantthanbenigntumours.�" @default.
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- W2023603014 date "2009-01-01" @default.
- W2023603014 modified "2023-09-26" @default.
- W2023603014 title "The Importance of Growth Factors and Steroid Hormones in Ovarian Cancer" @default.
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- W2023603014 doi "https://doi.org/10.1159/000246764" @default.
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