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• W2023603904 endingPage "034106" @default.
• W2023603904 startingPage "034106" @default.
• W2023603904 abstract "This paper presents a novel continuous tool-path planning methodology for hollowed scaffold fabrication in tissue engineering. A new functionally gradient porous architecture is proposed with a continuous material deposition planning scheme. A controllable variational pore size and hence the porosity have been achieved with a combination of two geometrically oriented consecutive layers. The desired porosity has been achieved with consecutive layers by geometrically partitioning each layer into sub-regions based on the area and the tissue scaffold design constraints. A continuous, interconnected and optimized tool-path for layers has been generated for a three-dimensional biomaterial deposition/printing process. A zigzag pattern tool-path has been proposed for an accumulated sub-region layer, and a concentric spiral-like optimal tool-path pattern has been generated for the successive layer to ensure continuity along the structure. Three-dimensional layers, formed by the proposed tool-path plan, vary the pore size and the porosity based on the biological and mechanical requirements. Several examples demonstrate the proposed methodology along with illustrative results. Also a comparative study between the proposed design and conventional Cartesian coordinate scaffolds has been performed. The results demonstrate a significant reduction in design error with the proposed method. Moreover, sample examples have been fabricated using a micro-nozzle biomaterial deposition system, and characterized for validation." @default.
• W2023603904 created "2016-06-24" @default.
• W2023603904 creator A5050982596 @default.
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• W2023603904 date "2011-07-01" @default.
• W2023603904 modified "2023-09-23" @default.
• W2023603904 title "A functionally gradient variational porosity architecture for hollowed scaffolds fabrication" @default.
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• W2023603904 doi "https://doi.org/10.1088/1758-5082/3/3/034106" @default.
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